Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium

被引：57

作者：

Huang, Ruyi ^{[1
,2
,3
]}

Wei, Yongyue ^{[1
,37
,41
]}

Hung, Rayjean J. ^{[4
]}

Liu, Geoffrey ^{[5
]}

Su, Li ^{[1
]}

Zhang, Ruyang ^{[1
,37
,41
]}

Zong, Xuchen ^{[4
]}

Zhang, Zuo-Feng ^{[6
]}

Morgenstern, Hal ^{[7
,8
]}

Brueske, Irene ^{[9
]}

Heinrich, Joachim ^{[9
]}

Hong, Yun-Chul ^{[10
]}

Kim, Jin Hee ^{[11
]}

Cote, Michele ^{[12
,13
]}

Wenzlaff, Angela ^{[12
,13
]}

Schwartz, Ann G. ^{[12
,13
]}

Stucker, Isabelle ^{[14
]}

Mclaughlin, L. John ^{[15
]}

Marcus, Michael W. ^{[16
]}

Davies, Michael P. A. ^{[16
]}

Liloglou, Triantafillos ^{[16
]}

Field, John K. ^{[16
]}

Matsuo, Keitaro ^{[17
]}

Barnett, Matt ^{[18
]}

Thornquist, Mark ^{[18
]}

Goodman, Gary ^{[18
]}

Wang, Yi ^{[19
,20
]}

Chen, Size ^{[19
,21
]}

Yang, Ping ^{[19
]}

Duell, Eric J. ^{[22
]}

Andrew, Angeline S. ^{[23
]}

Lazarus, Philip ^{[24
]}

Muscat, Joshua ^{[24
]}

Woll, Penella ^{[25
]}

Horsman, Janet ^{[25
]}

Teare, M. Dawn ^{[25
]}

Flugelman, Anath ^{[26
,27
]}

Rennert, Gad ^{[26
,27
]}

Zhang, Yan ^{[28
]}

Brenner, Hermann ^{[28
,29
]}

Stegmaier, Christa ^{[30
]}

van der Heijden, Erik H. F. M. ^{[31
]}

Aben, Katja ^{[31
,32
]}

Kiemeney, Lambertus ^{[31
]}

Barros-Dios, Juan ^{[33
]}

Perez-Rios, Monica ^{[33
]}

Ruano-Ravina, Alberto ^{[33
]}

Caporaso, Neil E. ^{[34
]}

Bertazzi, Pier Alberto ^{[35
,36
]}

Landi, Maria Teresa ^{[35
,36
]}

机构：

[1] Harvard Univ, TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[2] E Da Hosp, Dept Med Educ, Kaohsiung, Taiwan

[3] I Shou Univ, Kaohsiung, Taiwan

[4] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada

[5] Univ Toronto, Princess Margaret Canc Ctr, Univ Hlth Network, Toronto, ON, Canada

[6] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Jonsson Comprehens Canc Ctr, Dept Epidemiol, Los Angeles, CA USA

[7] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

[9] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Neuherberg, Germany

[10] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 151, South Korea

[11] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth, Seoul, South Korea

[12] Wayne State Univ, Barbara Ann Karmanos Canc Inst, Detroit, MI USA

[13] Wayne State Univ, Dept Oncol, Detroit, MI USA

[14] French Inst Hlth & Med Res, Ctr Res Epidemiol & Populat Hlth, Villejuif, France

[15] Publ Hlth Ontario, Toronto, ON, Canada

[16] Univ Liverpool, Inst Translat Med, Dept Mol & Clin Canc Med, Liverpool L69 3BX, Merseyside, England

[17] Aichi Canc Ctr, Res Inst, Div Mol Med, Nagoya, Aichi 464, Japan

[18] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[19] Mayo Clin, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN USA

[20] Wenzhou Med Univ, Sch Environm Sci & Publ Hlth, Wenzhou, Peoples R China

[21] Guangdong Pharmaceut Univ, Affiliated Hosp 1, Dept Oncol, Guangzhou, Guangdong, Peoples R China

[22] Catalan Inst Oncol ICO IDIBELL, Unit Nutr & Canc, Barcelona, Spain

[23] Dartmouth Coll, Norris Cotton Canc Ctr, Geisel Sch Med, Lebanon, NH 03756 USA

[24] Penn State Coll Med, Hershey, PA USA

[25] Univ Sheffield, Sheffield Sch Hlth & Related Res, Expt Canc Med Ctr, Sheffield, S Yorkshire, England

[26] Carmel Hosp, Clalit Natl Israeli Canc Control Ctr, Haifa, Israel

[27] Technion Israel Inst Technol, IL-32000 Haifa, Israel

[28] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[29] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[30] Saarland Canc Registry, Saarbrucken, Germany

[31] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, NL-6525 ED Nijmegen, Netherlands

[32] Netherlands Comprehens Canc Org, Utrecht, Netherlands

[33] Univ Hosp Complex Santiago Compostela, Serv Prevent Med, Santiago De Compostela, Spain

[34] NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA

[35] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Epidemiol Unit, Milan, Italy

[36] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[37] Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Epidemiol & Biostat,Sch Publ Hlth, Nanjing, Jiangsu, Peoples R China

[38] Univ Oviedo, Dept Prevent Med & Publ Hlth, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Oviedo, Spain

[39] CSIC, Dept Conservat Biol, Estn Biol Donana, E-41080 Seville, Spain

[40] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Pulm & Crit Care Div,Dept Med, Boston, MA USA

[41] Nanjing Med Univ, Sch Publ Hlth, Joint Lab Hlth & Environm Risk Assessment HERA, Nanjing, Jiangsu, Peoples R China

来源：

EBIOMEDICINE | 2015年 / 2卷 / 11期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

Smoking behaviors; Chronic obstructive pulmonary disease; Small cell lung cancer risk; Multicenter pooling; Causal mediation analysis; GENETIC SUSCEPTIBILITY; RESIDENTIAL RADON; DNA-REPAIR; RISK; COPD; VARIANTS; HEALTH; VALIDATION; EXPERIENCE; MEDIATION;

D O I：

10.1016/j.ebiom.2015.09.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%(quit_for_5-9 years) to 89%(quit_for_>= 20 years) declined SCLC risk vs. subjects who had quit smoking <5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects. Interpretation: This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：1677 / 1685

页数：9

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