Prone Positioning and Neuromuscular Blocking Agents as Adjunctive Therapies in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome

被引:2
作者
Guerin, Claude [1 ,2 ,3 ]
Cour, Martin [1 ,2 ]
Argaud, Laurent [1 ,2 ]
机构
[1] Hop Edouard Herriot, Med Intens Reanimat, Lyon, France
[2] Univ Lyon, Fac Med Lyon Est, Lyon, France
[3] Inst Mondor Rech Blomed, INSERM CNRS 955 7200, Creteil, France
关键词
acute respiratory distress syndrome; prone position; neuromuscular blocking agents; lung protective ventilation; COVID-19; COMPUTED-TOMOGRAPHIC DENSITY; GAS-EXCHANGE; SURVIVAL; COVID-19; FAILURE; DISEASE; OXYGENATION; IMPROVEMENT; PRESSURES; MORTALITY;
D O I
10.1055/s-0042-1744304
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Neuromuscular blocking agents (NMBAs) and prone position (PP) are two major adjunctive therapies that can improve outcome in moderate-to-severe acute respiratory distress syndrome. NMBA should be used once lung-protective mechanical ventilation has been set, for 48 hours or less and as a continuous intravenous infusion. PP should be used as early as possible for long sessions; in COVID-19 its use has exploded. In nonintubated patients, PP might reduce the rate of intubation but not mortality. The goal of this article is to perform a narrative review on the pathophysiological rationale, the clinical effects, and the clinical use and recommendations of both NMBA and PP.
引用
收藏
页码:453 / 460
页数:8
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