Structural and Pharmacological Features of Phospholipases A2 from Snake Venoms

被引：42

作者：

de Paula, Rafael Cisne ^{[1
]}

Castro, Helena Carla ^{[1
]}

Rodrigues, Carlos Rangel ^{[2
]}

Melo, Paulo Assis ^{[3
]}

Fuly, Andre Lopes ^{[1
]}

机构：

[1] Univ Fed Fluminense, Inst Biol, Dept Biol Celular & Mol, Niteroi, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Fac Farm, ModMolQSAR, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Dept Farmacol Basica & Clin, Rio De Janeiro, Brazil

来源：

PROTEIN AND PEPTIDE LETTERS | 2009年 / 16卷 / 08期

关键词：

Phospholipases A(2); snake venom; mechanism of action; inhibitors; lysophosphatidylcholine; binding receptors; BOTHROPS-JARARACUSSU VENOM; PLATELET-ACTIVATING-FACTOR; LYSOPHOSPHATIDYLCHOLINE INDUCES APOPTOSIS; 2.7 ANGSTROM RESOLUTION; HUMAN ENDOTHELIAL-CELLS; ASPER MYOTOXIN-II; SKELETAL-MUSCLE; FUNCTIONAL-CHARACTERIZATION; CRYSTAL-STRUCTURE; FATTY-ACID;

D O I：

10.2174/092986609788923365

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipases A(2) enzymes are found in many biological sources, including snake venoms. Here we reviewed aspects of PLA(2)s including biological and structural features, interaction with binding receptors, inhibitors used on structure-function relationship studies and highlighting the mechanism of action and role of the snake venom PLA(2)s products, the lysophosphatidylcholine.

引用

页码：899 / 907

页数：9

共 117 条

[1] A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change [J].

Ambrosio, ALB ;

Nonato, MC ;

de Araújo, HSS ;

Arni, R ;

Ward, RJ ;

Ownby, CL ;

de Souza, DHF ;

Garratt, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (08) :7326-7335

[2] Systemic hemorrhage induced by proteinase H from Crotalus adamanteus (eastern diamondback rattlesnake) venom [J].

Anderson, SG ;

Ownby, CL .

TOXICON, 1997, 35 (08) :1301-1313

[3] Structural and functional characterization of an acidic platelet aggregation inhibitor and hypotensive phospholipase A2 from Bothrops jararacussu snake venom [J].

Andriao-Escarso, SH ;

Soares, AM ;

Fontes, MRM ;

Fuly, AL ;

Corrêa, FMA ;

Rosa, JC ;

Greene, LJ ;

Giglio, JR .

BIOCHEMICAL PHARMACOLOGY, 2002, 64 (04) :723-732

[4] Effect of suramin on myotoxicity of some crotalid snake venoms [J].

Arruda, EZ ;

Silva, NMV ;

Moraes, RAM ;

Melo, PA .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2002, 35 (06) :723-726

[5] Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions [J].

Austin, SC ;

Funk, CD .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1999, 58 (5-6) :231-252

[6]

Boechat Antonio Luiz R., 2001, Revista do Instituto de Medicina Tropical de Sao Paulo, V43, P7, DOI 10.1590/S0036-46652001000100002

[7] Isolation and enzymatic characterization of a basic phospholipase A2 from Bothrops jararacussu snake venom [J].

Bonfim, VL ;

Toyama, MH ;

Novello, JC ;

Hyslop, S ;

Oliveira, CRB ;

Rodrigues-Simioni, L ;

Marangoni, S .

JOURNAL OF PROTEIN CHEMISTRY, 2001, 20 (03) :239-245

[8] Reversible skeletal neuromuscular paralysis induced by different lysophospholipids [J].

Caccin, Paola ;

Rigoni, Michela ;

Bisceglie, Alessandra ;

Rossetto, Ornella ;

Montecucco, Cesare .

FEBS LETTERS, 2006, 580 (27) :6317-6321

[9] Inhibition of the myotoxic activity of Bothrops asper myotoxin II in mice by immunization with its synthetic 13-mer peptide 115-129 [J].

Calderón, L ;

Lomonte, B .

TOXICON, 1999, 37 (04) :683-687

[10] Immunochemical characterization and role in toxic activities of region 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom [J].

Calderón, L ;

Lomonte, B .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1998, 358 (02) :343-350

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