New drug approvals for 2020: Synthesis and clinical applications

被引：42

作者：

Yuan, Shuo ^{[1
,2
]}

Luo, Yong-Qiang ^{[1
,2
]}

Zuo, Jia-Hui ^{[1
,2
]}

Liu, Hui ^{[1
,2
]}

Li, Fang ^{[1
,2
]}

Yu, Bin ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Mil Educ, Zhengzhou 450001, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 215卷

基金：

中国国家自然科学基金;

关键词：

New drugs; Chemical synthesis; Clinical applications; FARNESYL-PROTEIN TRANSFERASE; PEPTIDE CGRP; OPEN-LABEL; PHASE-III; DISCOVERY; INHIBITORS; EFFICACY; POTENT; SELPERCATINIB; MULTICENTER;

D O I：

10.1016/j.ejmech.2021.113284

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

53 New drugs including 38 chemical entities and 15 biologics were approved by the U.S. Food and Drug Administration during 2020. Among the marketed drugs, 34 new small molecule drugs and 4 new diagnostic agents with privileged structures and novel clinical applications represent as promising leads for the development of new drugs with the similar indications and improved therapeutic efficacy. This review is mainly focused on the clinical applications and synthetic methods of 34 small-molecule drugs newly approved by the FDA in 2020. (c) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：34

共 50 条

[21] Drug updates and approvals: 2018 in review [J].

Mospan, Cortney ;

Mospan, Geoffrey ;

Byland, Emily ;

Whitaker, William Blake ;

Xiong, Linda ;

Dunlap, Jordan ;

Canupp, Katherine .

NURSE PRACTITIONER, 2018, 43 (12) :23-32

[22] Comparing timelines and evidence available to support new TB, HIV, and HCV drug approvals: The same, only different [J].

LaHood, Allison ;

Rahman, Rifat ;

McKenna, Lindsay ;

Frick, Mike ;

Mitnick, Carole D. .

PLOS ONE, 2022, 17 (07)

[23] Perspectives on 2015 Drug and Treatment Approvals [J].

Mohundro, Michael M. .

AMERICAN JOURNAL OF MANAGED CARE, 2015, 21 (06) :5-8

[24] Drug updates and approvals: 2019 in review [J].

Crump, Lauren Hartsell ;

Benfield, Miranda ;

Ramey, Caleb ;

Arcara, Ashley ;

Yang, Sebin ;

Brown, Jenna ;

Mospan, Geoffrey ;

Mospan, Cortney .

NURSE PRACTITIONER, 2019, 44 (12) :21-32

[25] Synthesis and clinical application of new drugs approved by FDA in 2022 [J].

Zhang, Jing-Yi ;

Wang, Ya-Tao ;

Sun, Lu ;

Wang, Sai-Qi ;

Chen, Zhe-Sheng .

MOLECULAR BIOMEDICINE, 2023, 4 (01)

[26] Synthesis and clinical application of new drugs approved by FDA in 2023 [J].

Wang, Ya-Tao ;

Yang, Peng-Cheng ;

Zhang, Yan-Feng ;

Sun, Jin-Feng .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 265

[27] Chlorpheniramine, an Old Drug with New Potential Clinical Applications: A Comprehensive Review of the Literature [J].

Rizvi, Syed A. A. ;

Ferrer, Gustavo ;

Khawaja, Uzzam A. ;

Sanchez-Gonzalez, Marcos A. .

CURRENT REVIEWS IN CLINICAL AND EXPERIMENTAL PHARMACOLOGY, 2024, 19 (02) :137-145

[28] Approvals in 2022: overall survival, dose optimization, new approvals and beyond [J].

Telaraja, Deepti ;

Gormley, Nicole ;

Pazdur, Richard .

NATURE REVIEWS CLINICAL ONCOLOGY, 2023, 20 (04) :207-208

[29] US FDA oncology drug approvals in 2014 [J].

Wolford, Juliet E. ;

Tewari, Krishnansu S. .

FUTURE ONCOLOGY, 2015, 11 (13) :1931-1945

[30] Small molecule anticancer drugs approved during 2021-2022: Synthesis and clinical applications [J].

Tamatam, Rekha ;

Mohammed, Arifullah .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 272

← 1 2 3 4 5 →