Development of photolabile protecting groups and their application to the optochemical control of cell signaling

被引:82
作者
Bardhan, Anirban [1 ]
Deiters, Alexander [1 ]
机构
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
CAGED COMPOUNDS; AMINOBUTYRIC-ACID; PROTEIN FUNCTION; CAGING GROUP; ONE-PHOTON; 2-PHOTON; BODIPY; DESIGN; PROBES; ABSORPTION;
D O I
10.1016/j.sbi.2019.03.028
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many biological processes are naturally regulated with spatiotemporal control. In order to perturb and investigate them, optochemical tools have been developed that convey similar spatiotemporal precision. Pivotal to optochemical probes are photolabile protecting groups, so called caging groups, and recent developments have enabled new applications to cellular processes, including cell signaling. This review focuses on the advances made in the field of caging groups and their application in cell signaling through caged molecules such as neurotransmitters, lipids, secondary messengers, and proteins.
引用
收藏
页码:164 / 175
页数:12
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