A novel vaccine adjuvant based on straight polyacrylate potentiates vaccine-induced humoral and cellular immunity in cynomolgus macaques

被引:5
|
作者
Pavot, Vincent [1 ]
Bisceglia, Helene [1 ]
Guillaume, Florine [1 ]
Montano, Sandrine [1 ]
Zhang, Linong [2 ]
Boudet, Florence [1 ]
Haensler, Jean [1 ]
机构
[1] Sanofi Pasteur, Res & Dev Dept, Marcy Letoile, France
[2] Sanofi Pasteur, Res & Dev Dept, Cambridge, MA USA
关键词
Adjuvant; humoral immunity; memory B cells; cell-mediated immunity; mucosal immunity;
D O I
10.1080/21645515.2020.1855956
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Adjuvants are central to the efficacy of subunit vaccines. Although several new adjuvants have been approved in human vaccines over the last decade, the panel of adjuvants in licensed human vaccines remains small. There is still a need for novel adjuvants that can be safely used in humans, easy to source and to formulate with a wide range of antigens and would be broadly applicable to a wide range of vaccines. In this article, using the Respiratory Syncytial Virus (RSV) nanoparticulate prefusion F model antigen developed by Sanofi, we demonstrate in the macaque model that the polyacrylate (PAA)-based adjuvant SPA09 is well tolerated and increases vaccine antigen-specific humoral immunity (sustained neutralizing antibodies, memory B cells and mucosal immunity) and elicits strong T(H)1-type responses (based on IFN gamma and IL-2 ELISpots) in a dose-dependent manner. These data warrant further development of the SPA09 adjuvant for evaluation in clinical trial.
引用
收藏
页码:2336 / 2348
页数:13
相关论文
共 50 条
  • [31] Liposome-Based Carbohydrate Vaccine for Simultaneously Eliciting Humoral and Cellular Antitumor Immunity
    Yao, Lintong
    Wu, Libin
    Wang, Rujin
    Liu, Yu
    Luo, Feifei
    Chen, Guosong
    Zhang, Yufei
    ACS MACRO LETTERS, 2022, 11 (08) : 975 - 981
  • [32] Sars-Cov-2 Vaccine-Induced Cellular and Humoral Immunity in Patients after CD19.CAR-T Cell Therapy
    Reimann, Hannah
    Kremer, Anita Natalie
    Blumenberg, Viktoria
    Schmidt, Katja
    Aigner, Michael
    Kremer, Andreas
    Tenbusch, Matthias
    Bruns, Heiko
    Harrer, Thomas
    Schett, Georg
    Mueller, Fabian
    Mackensen, Andreas
    Subklewe, Marion
    Voelkl, Simon
    BLOOD, 2022, 140 : 10279 - 10280
  • [33] Chemokine Receptor 7 Is Essential for Coxiella burnetii Whole-Cell Vaccine-Induced Cellular Immunity but Dispensable for Vaccine-Mediated Protective Immunity
    Chen, Chen
    van Schaik, Erin J.
    Gregory, Anthony E.
    Vigil, Adam
    Felgner, Phillip L.
    Hendrix, Laura R.
    Faris, Robert
    Samuel, James E.
    JOURNAL OF INFECTIOUS DISEASES, 2019, 220 (04): : 624 - 634
  • [34] Effectiveness and Durability of mRNA Vaccine-Induced SARS-CoV-2-Specific Humoral and Cellular Immunity in Severe Asthma Patients on Biological Therapy
    Podrazil, Michal
    Taborska, Pavla
    Stakheev, Dmitry
    Rataj, Michal
    Lastovicka, Jan
    Vlachova, Alena
    Pohunek, Petr
    Bartunkova, Jirina
    Smrz, Daniel
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [35] Vaccine-Induced Protection Against Furunculosis Involves Pre-emptive Priming of Humoral Immunity in Arctic Charr
    Braden, Laura M.
    Whyte, Shona K.
    Brown, Alyson B. J.
    Van Iderstine, Carter
    Letendre, Corinne
    Groman, David
    Lewis, Jeff
    Purcell, Sara L.
    Hori, Tiago
    Fast, Mark D.
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [36] Lack of Evidence on Association between Iron Deficiency and COVID-19 Vaccine-Induced Neutralizing Humoral Immunity
    Faizo, Arwa A.
    Bawazir, Asma A.
    Almashjary, Majed N. N.
    Hassan, Ahmed M. M.
    Qashqari, Fadi S. S.
    Barefah, Ahmed S. S.
    El-Kafrawy, Sherif A. A.
    Alandijany, Thamir A. A.
    Azhar, Esam I. I.
    VACCINES, 2023, 11 (02)
  • [37] A potential association between obesity and reduced effectiveness of COVID-19 vaccine-induced neutralizing humoral immunity
    Faizo, Arwa A.
    Qashqari, Fadi S.
    El-Kafrawy, Sherif A.
    Barasheed, Osamah
    Almashjary, Majed N.
    Alfelali, Mohammed
    Bawazir, Asma A.
    Albarakati, Boshra M.
    Khayyat, Soud A.
    Hassan, Ahmed M.
    Alandijany, Thamir A.
    Azhar, Esam, I
    JOURNAL OF MEDICAL VIROLOGY, 2023, 95 (01)
  • [38] Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2
    Dicks, Matthew D. J.
    Rose, Louisa M.
    Russell, Rebecca A.
    Bowman, Lesley A. H.
    Graham, Carl
    Jimenez-Guardeno, Jose M.
    Doores, Katie J.
    Malim, Michael H.
    Draper, Simon J.
    Howarth, Mark
    Biswas, Sumi
    MOLECULAR THERAPY, 2022, 30 (12) : 3639 - 3657
  • [39] Humoral and cellular immunity induced by tumor cell vaccine based on the chicken xenogeneic homologous matrix metalloproteinase-2
    T Yi
    Y-Q Wei
    L Tian
    X Zhao
    J Li
    H-X Deng
    Y-J Wen
    C-H Zou
    G-H Tan
    B Kan
    J-M Su
    Y Jiang
    Y-Q Mao
    P Chen
    Y-S Wang
    Cancer Gene Therapy, 2007, 14 : 158 - 164
  • [40] Humoral and cellular immunity induced by tumor cell vaccine based on the chicken xenogeneic homologous matrix metalloproteinase-2
    Yi, T.
    Wei, Y-Q
    Tian, L.
    Zhao, X.
    Li, J.
    Deng, H-X
    Wen, Y-J
    Zou, C-H
    Tan, G-H
    Kan, B.
    Su, J-M
    Jiang, Y.
    Mao, Y-Q
    Chen, P.
    Wang, Y-S
    CANCER GENE THERAPY, 2007, 14 (02) : 156 - 164