Cu-Catalyzed Aminoacyloxylation of Unactivated Alkenes of Unsaturated Hydrazones with Manifold Carboxylic Acids toward Ester-Functionalized Pyrazolines

被引：35

作者：

Liu, Rui-Hua ^{[1
]}

Wang, Zi-Qing ^{[1
]}

Wei, Bang-Yi ^{[1
]}

Zhang, Jian-Wu ^{[1
]}

Zhou, Bo ^{[1
]}

Han, Bing ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 14期

基金：

中国国家自然科学基金;

关键词：

UREA-TETHERED ALKENES; INTRAMOLECULAR AMINOHYDROXYLATION; AQUEOUS-SOLUTION; BOND-CLEAVAGE; AMINOOXYGENATION; OLEFINS; DIAMINATION; CYCLIZATION; ASPIRIN; AMINO;

D O I：

10.1021/acs.orglett.8b01507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed aminoacyloxylation of unactivated alkenes of unsaturated hydrazones is achieved by using various commercially available carboxylic acids as the acyloxylating reagents and di-tert-butyl peroxide (DTBP) as the oxidant. By using this method, a sequence of structurally diversiform acyloxyl-substituted pyrazolines are efficiently synthesized. Significantly, many carboxyl-containing drugs and bioactive molecules with unprotected functional groups are compatible in this reaction.

引用

页码：4183 / 4186

页数：4

共 2 条

[1] Cu-catalyzed hydrofluoroacetylation of alkynes or alkynyl carboxylic acids leading highly stereoselectively to fluoroacetylated alkenes
Ke, Miaolin
Feng, Qiang
Yang, Kai
Song, Qiuling
ORGANIC CHEMISTRY FRONTIERS, 2016, 3 (02): : 150 - 155
[2] Cu-Catalyzed Formal Methylative and Hydrogenative Carboxylation of Alkynes with Carbon Dioxide: Efficient Synthesis of α,β-Unsaturated Carboxylic Acids
Takimoto, Masanori
Hou, Zhaomin
CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (34) : 11439 - 11445

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