Benzimidazoles: A biologically active compounds

被引：178
|
作者：
Salahuddin [1 ]
Shaharyar, Mohammad [2 ]
Mazumder, Avijit [1 ]
机构：
[1] Noida Inst Engn & Technol, Dept Pharmaceut Technol, Knowledge Park 2, Greater Noida 201306, India
[2] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2017年 / 10卷
关键词：
Benzimidazole; Pharmacological activity; Antimicrobial activity; ANTIBACTERIAL ACTIVITY; ANTICANCER ACTIVITY; DERIVATIVES; 1H-BENZIMIDAZOLE; ANTIPROTOZOAL; INHIBITORS;
D O I：
10.1016/j.arabjc.2012.07.017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthesis of commercially available benzimidazole involves condensation of o-phenylenediamine with formic acid. The most prominent benzimidazole compound in nature is N-riosyldimethylbenzimidazole, which serves as a axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc. The substituted benzimidazoles are summarized in this review to know about the chemistry as well as pharmacological activities. (C) 2012 Production and hosting by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：S157 / S173
页数：17
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