Transmission with cascaded optical regeneration based on synchronous modulation combined with optical reshaping by cross-gain compression in a semiconductor optical amplifier is investigated at 43 Gb/s over transoceanic distances (10 000 km). The proposed optical regenerator configuration performs signal reshaping and retiming while preserving the input signal wavelength. The regenerator cascadability properties are investigated using a reconfigurable loop to assess the impact of different inter-regeneration spacing on the transmission signal properties.