Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway

被引：291

作者：

Luo, Xiang-Hang ^{[1
]}

Guo, Li-Juan ^{[1
]}

Xie, Hui ^{[1
]}

Yuan, Ling-Qing ^{[1
]}

Wu, Xian-Ping ^{[1
]}

Zhou, Hou-De ^{[1
]}

Liao, Er-Yuan ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Inst Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

adiponectin; osteoblast; osteoclast; RANKL; osteoprotegerin;

D O I：

10.1359/JBMR.060707

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our study indicates that recombinant adiponectin induced RANKL and inhibited OPG expression in human osteoblasts through the AdipoR1/p38 MAPK pathway, and these responses contributed to the adiponectin-induced osteoclasts formation in the co-culture of osteoblast and peripheral blood monocytes systems. These findings showed that adiponectin increased osteoclast formation indirectly through stimulating RANKL and inhibiting OPG production in osteoblasts. It also suggests the pharmacological nature of recombinant adiponectin that indirectly induces osteoclasts formation.

引用

页码：1648 / 1656

页数：9

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