Fluorinated Lipid Constructs Permit Facile Passage of Molecular Cargo into Living Cells

被引：29

作者：

Dafik, Laila ^{[1
]}

Kalsani, Venkateshwarlu ^{[1
]}

Leung, Anthony Kar Lun ^{[2
]}

Kumar, Krishna ^{[1
,3
]}

机构：

[1] Tufts Univ, Dept Chem, Medford, MA 02155 USA

[2] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[3] Tufts Med Ctr, Ctr Canc, Boston, MA 02110 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 34期

基金：

美国国家科学基金会;

关键词：

RECEPTOR-MEDIATED ENDOCYTOSIS; NBD-LABELED PHOSPHATIDYLCHOLINE; CARBON NANOTUBES; PHOSPHOLIPID-BILAYERS; SURFACE-RECEPTORS; SYNTHETIC MIMICS; MAMMALIAN-CELLS; COILED COILS; DELIVERY; PROTEINS;

D O I：

10.1021/ja902777d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorinated lipids get rapidly internalized into living cells and are also displayed on the cell surface. The uptake of lipids is energy dependent and is likely via the clathrin-mediated endocytic pathway. Fluorinated lipids are 3-5-fold more efficient in acting as molecular transporters of noncovalently bound proteins than their hydrocarbon counterparts. These materials could serve as efficient molecular transporters for molecules that function in the cytoplasm such as short interfering RNAs (siRNAs)

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页码：12091 / +

页数：5

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