Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy

被引:124
作者
Lees, Justin G. [1 ]
Makker, Preet G. S. [1 ]
Tonkin, Ryan S. [1 ]
Abdulla, Munawwar [1 ]
Park, Susanna B. [2 ,3 ]
Goldstein, David [3 ,4 ]
Moalem-Taylor, Gila [1 ]
机构
[1] Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia
[2] Univ Sydney, Brain & Mind Ctr, Camperdown, NSW 2050, Australia
[3] Univ New South Wales, Prince Wales Clin Sch, Sydney, NSW 2052, Australia
[4] Prince Wales Hosp, Dept Med Oncol, Sydney, NSW 2031, Australia
关键词
Chemotherapy-induced peripheral neuropathy; Neurotoxicity; Neuroinflammation; Immune cell activation; Hypersensitivity; Paraesthesia; INDUCED MECHANICAL ALLODYNIA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; NECROSIS-FACTOR-ALPHA; DORSAL-ROOT GANGLION; REGULATORY T-CELLS; GLIAL-CELLS; SPINAL-CORD; SCHWANN-CELLS; LANGERHANS CELLS; SENSORY NEURONS;
D O I
10.1016/j.ejca.2016.12.006
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain are challenging complications of cancer treatment. Many of the major classes of chemotherapeutics can cause neurotoxicity and significantly modulate the immune system. There is ongoing investigation regarding whether reciprocal crosstalk between the nervous and immune systems occurs and, indeed, contributes to neuropathic pain during treatment with chemotherapeutics. An emerging concept is that neuroinflammation is one of the major mechanisms underlying CIPN. Here, we discuss recent findings, which provide insight into this complex process of neuroimmune interactions. Findings show limited infiltration of leukocytes into the nervous system of CIPN animals and varying degrees of peripheral and central glial activation depending on the chemotherapeutic drug, dose, schedule, and timing. Most evidence suggests an increase in pro-inflammatory cytokine expression and changes in immune signalling pathways. There is, however, limited evidence available from human studies and it remains unclear whether neuroinflammatory responses are the cause of neuropathy or a bystander effect of the chemotherapy treatment. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:22 / 29
页数:8
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