Personalized glucose-insulin model based on signal analysis

被引:4
作者
Goede, Simon L. [1 ]
de Galan, Bastiaan E. [2 ]
Leow, Melvin Khee Shing [3 ,4 ]
机构
[1] Syst Res, Oterlekerweg 4, NL-1841 GP Stompetoren, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Gen Internal Med, Postbus 9101, NL-6500 HB Nijmegen, Netherlands
[3] Tan Tock Seng Hosp, Dept Endocrinol, Singapore 308433, Singapore
[4] Nanyang Technol Univ, Off Clin Sci, Duke NUS Grad Med Sch, Singapore Lee Kong Chian Sch Med, Singapore, Singapore
关键词
Appearance profile; Model identification; Electrical network model; Simulation; Personalized target; Validation;
D O I
10.1016/j.jtbi.2016.12.018
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Glucose plasma measurements for diabetes patients are generally presented as a glucose concentration-time profile with 15-60 min time scale intervals. This limited resolution obscures detailed dynamic events of glucose appearance and metabolism. Measurement intervals of 15 min or more could contribute to imperfections in present diabetes treatment. High resolution data from mixed meal tolerance tests (MMTT) for 24 type 1 and type 2 diabetes patients were used in our present modeling. We introduce a model based on the physiological properties of transport, storage and utilization. This logistic approach follows the principles of electrical network analysis and signal processing theory. The method mimics the physiological equivalent of the glucose homeostasis comprising the meal ingestion, absorption via the gastrointestinal tract (GIT) to the endocrine nexus between the liver, pancreatic alpha and beta cells. This model demystifies the metabolic 'black box' by enabling in silico simulations and fitting of individual responses to clinical data. Five-minute intervals MMIT data measured from diabetic subjects result in two independent model parameters that characterize the complete glucose system response at a personalized level. From the individual data measurements, we obtain a model which can be analyzed with a standard electrical network simulator for diagnostics and treatment optimization. The insulin dosing time scale can be accurately adjusted to match the individual requirements of characterized diabetic patients without the physical burden of treatment.
引用
收藏
页码:333 / 342
页数:10
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