Acute Respiratory Distress Syndrome: Role of Oleic Acid-Triggered Lung Injury and Inflammation

被引：79
作者：
Goncalves-de-Albuquerque, Cassiano Felippe [1 ]
Silva, Adriana Ribeiro [1 ]
Burth, Patricia [2 ]
Castro-Faria, Mauro Velho [3 ]
Castro-Faria-Neto, Hugo Caire [1 ]
机构：
[1] Inst Oswaldo Cruz FIOCRUZ, Lab Imunofarmacol, BR-21040900 Rio De Janeiro, RJ, Brazil
[2] Univ Fed Fluminense, Inst Biol, Dept Biol Celular & Mol, BR-2402015 Niteroi, RJ, Brazil
[3] Univ Estado Rio de Janeiro, Fac Ciencias Med, Dept Med Interna, BR-20550900 Rio De Janeiro, RJ, Brazil
来源：
MEDIATORS OF INFLAMMATION | 2015年 / 2015卷
关键词：
FREE FATTY-ACIDS; NA/K-ATPASE; THERAPEUTIC TARGETS; ANIMAL-MODELS; PATHOGENESIS; RECEPTORS; PULMONARY; APELIN; MICE; GLYCOLIPOPROTEIN;
D O I：
10.1155/2015/260465
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lung injury especially acute respiratory distress syndrome (ARDS) can be triggered by diverse stimuli, including fatty acids and microbes. ARDS affects thousands of people worldwide each year, presenting high mortality rate and having an economic impact. One of the hallmarks of lung injury is edema formation with alveoli flooding. Animal models are used to study lung injury. Oleic acid-induced lung injury is a widely used model resembling the human disease. The oleic acid has been linked to metabolic and inflammatory diseases; here we focus on lung injury. Firstly, we briefly discuss ARDS and secondly we address the mechanisms by which oleic acid triggers lung injury and inflammation.
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页数：9
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