Asymmetric AB3 Miktoarm Star Polymers: Synthesis, Self-Assembly, and Study of Micelle Stability Using AF4 for Efficient Drug Delivery

被引：19
作者：
Moquin, Alexandre [1 ]
Sharma, Anjali [2 ]
Cui, Yiming [1 ]
Lau, Anthony [2 ]
Maysinger, Dusica [1 ]
Kakkar, Ashok [2 ]
机构：
[1] McGill Univ, Dept Pharmacol & Therapeut, 3655 Promenade Sir William Osler, Montreal, PQ H3G 1Y6, Canada
[2] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada
来源：
MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 12期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
amphiphilic miktoarm star polymer; drug delivery systems; field-flow fractionation; glioblastoma spheroids; micelles; RING-OPENING POLYMERIZATION; CLICK CHEMISTRY; CELL-DEATH; CURCUMIN; NANOCARRIERS; COPOLYMERS; BIOAVAILABILITY; NANOPARTICLES; COMBINATION; DESIGN;
D O I：
10.1002/mabi.201500186
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and versatile methodology, which employs a combination of ring-opening polymerization and alkyne-azide click chemistry to synthesize amphiphilic AB(3) miktoarm stars, is reported. Their aqueous self-assembly behavior was studied using dynamic light scattering, fluorescence, and asymmetrical flow field-flow fractionation (AF(4)). AB(3) miktoarm stars form micelles which incorporate curcumin with high efficiency, and significantly reduce the viability of glioblastoma cells in spheroids. We demonstrate that AF(4) is an effective technique to determine the size distribution of self-assembled structures exposed to a biological medium. The ease, with which asymmetric AB(3) miktoarm polymers are constructed, provides a platform that can be widely employed to deliver a variety of lipophilic drugs.
引用
收藏
页码：1744 / 1754
页数：11
相关论文
共 34 条
[1]   Bioavailability of curcumin: Problems and promises [J].
Anand, Preetha ;
Kunnumakkara, Ajaikumar B. ;
Newman, Robert A. ;
Aggarwal, Bharat B. .
MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818
[2]   RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo (Retracted article. See vol. 102, pg. 143, 2016) [J].
Anand, Preetha ;
Nair, Hareesh B. ;
Sung, Bokyung ;
Kunnumakkara, Ajaikumar B. ;
Yadav, Vivek R. ;
Tekmal, Rajeshwar R. ;
Aggarwal, Bharat B. .
BIOCHEMICAL PHARMACOLOGY, 2010, 79 (03) :330-338
[3]   Polymeric nanoparticle-encapsulated curcumin (nanocurcumin"): A novel strategy for human cancer therapy" [J].
Bisht S. ;
Feldmann G. ;
Soni S. ;
Ravi R. ;
Karikar C. ;
Maitra A. ;
Maitra A. .
Journal of Nanobiotechnology, 5 (1)
[4]   Dual Thermo- and pH-Responsive Zwitterionic Sulfobataine Copolymers for Oral Delivery System [J].
Chen, Ching-Yi ;
Wang, Hsiang-Ling .
MACROMOLECULAR RAPID COMMUNICATIONS, 2014, 35 (17) :1534-1540
[5]   Self-Assembly Strategy for the Preparation of Polymer-Based Nanoparticles for Drug and Gene Delivery [J].
Chen, Si ;
Cheng, Si-Xue ;
Zhuo, Ren-Xi .
MACROMOLECULAR BIOSCIENCE, 2011, 11 (05) :576-589
[6]   Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics (Theranostics) [J].
Chen, Wei ;
Xu, Naifeng ;
Xu, Liguang ;
Wang, Libing ;
Li, Zuokun ;
Ma, Wei ;
Zhu, Yingyue ;
Xu, Chuanlai ;
Kotov, Nicholas A. .
MACROMOLECULAR RAPID COMMUNICATIONS, 2010, 31 (02) :228-236
[7]   "Click" Chemistry-Mediated Phenylene-Cored Carborane Dendrimers [J].
Dash, Barada Prasanna ;
Satapathy, Rashmirekha ;
Bode, Barrie P. ;
Reidl, Cory T. ;
Sawicki, James W. ;
Mason, Allen J. ;
Maguire, John A. ;
Hosmane, Narayan S. .
ORGANOMETALLICS, 2012, 31 (07) :2931-2935
[8]   Constructing well-defined star graft copolymers [J].
Deng, Yan ;
Zhang, Sen ;
Lu, Guolin ;
Huang, Xiaoyu .
POLYMER CHEMISTRY, 2013, 4 (05) :1289-1299
[9]   Noncovalent interaction-assisted polymeric micelles for controlled drug delivery [J].
Ding, Jianxun ;
Chen, Linghui ;
Xiao, Chunsheng ;
Chen, Li ;
Zhuang, Xiuli ;
Chen, Xuesi .
CHEMICAL COMMUNICATIONS, 2014, 50 (77) :11274-11290
[10]  
Franc G, 2010, CHEM SOC REV, V39, P1536, DOI 10.1039/b913281n
1234