Adolescent Idiopathic Scoliosis and the Single-nucleotide Polymorphism of the Growth Hormone Receptor and IGF-1 Genes

被引：25

作者：

Yang, Yong ^{[1
]}

Wu, Zhihong ^{[1
]}

Zhao, Taimao ^{[1
]}

Wang, Hai ^{[1
]}

Zhao, Dong ^{[2
]}

Zhang, Jianguo ^{[1
]}

Wang, Yipeng ^{[1
]}

Ding, Yaozhong ^{[3
]}

Qiu, Guixing ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Dept Orthoped, Peking Union Med Coll, Beijing 100037, Peoples R China

[2] Tianjin Hosp, Dept Orthoped, Tianjin, Peoples R China

[3] Mt Sinai Sch Med, Recanati Miller Transplantat Inst, New York, NY USA

来源：

ORTHOPEDICS | 2009年 / 32卷 / 06期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.3928/01477447-20090511-08

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The etiology of adolescent idiopathic scoliosis is undetermined despite years of research. A number of hypotheses have been postulated to explain its development, including growth abnormalities. The irregular expression of growth hormone and insulin-like growth factor-1 (IGF-1) may disturb hormone metabolism, result in a gross asymmetry, and promote the progress of adolescent idiopathic scoliosis. Initial association studies in complex diseases have demonstrated the power of candidate gene association. Prior to our study, 1 study in this field had a negative result. A replicable study is vital for reliability. To determine the relationship of growth hormone receptor and IGF-1 genes with adolescent idiopathic scoliosis, a population-based association study was performed. Single nucleotide polymorphisms with potential function were selected from candidate genes and a distribution analysis was performed. A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese. Copyright ® 2009 SLACK Incorporated. All rights reserved.

引用

页码：411 / 411

页数：1

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