A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels

被引：21

作者：

Amo, Gemma ^{[1
]}

Garcia-Menaya, Jesus ^{[2
]}

Campo, Paloma ^{[3
]}

Cordobes, Concepcion ^{[2
]}

Plaza Seron, M. Carmen ^{[1
,3
]}

Ayuso, Pedro ^{[4
]}

Esguevillas, Gara ^{[1
]}

Blanca, Miguel ^{[3
]}

Agundez, Jose A. G. ^{[1
]}

Garcia-Martin, Elena ^{[1
]}

机构：

[1] Univ Extremadura, Dept Pharmacol, Caceres, Spain

[2] Univ Hosp Infanta Cristina, Allergy Serv, Badajoz, Spain

[3] Hosp Carlos Haya, Allergy Serv, Malaga, Spain

[4] Univ Malaga, Gen Hosp, IBIMA, Res Lab, E-29071 Malaga, Spain

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

FC-EPSILON-RI; GENOME-WIDE ASSOCIATION; HUMAN BASOPHILS; GENE PROMOTER; BETA-CHAIN; IN-VITRO; ASTHMA; RECEPTOR; POLYMORPHISMS; VARIANTS;

D O I：

10.1038/srep19724

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the high-affinity IgE receptor (Fc epsilon RI), which is polymorphic. Studies analyzing the association between allergic rhinitis and Fc epsilon RI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in Fc epsilon RI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08-0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08-0.88, P = 0.020). These two SNPs are linked (D' = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.

引用

页数：7

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