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Regulatory T Cells and Extracorporeal Photochemotherapy: Correlation With Clinical Response and Decreased Frequency of Proinflammatory T Cells
被引:61
作者:

Di Biaso, Iolanda
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Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy

Di Maio, Lucia
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Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy

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Balduzzi, Adriana
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Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy

Parma, Matteo
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机构:
San Gerardo Hosp, Bone Marrow Transplantat Unit, Dept Adult Hematol, Milan, Italy Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy

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Perseghin, Paolo
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San Gerardo Hosp, Dept Clin Pathol, Immunohematol & Transfus Therapeut Aphaeresis Uni, Milan, Italy Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy

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Biagi, Ettore
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机构: Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy
机构:
[1] Univ Milano Bicocca, San Gerardo Hosp, Dept Pediat, Lab Cell Therapy Stefano Verri, I-20052 Milan, Italy
[2] San Gerardo Hosp, Bone Marrow Transplantat Unit, Dept Adult Hematol, Milan, Italy
[3] San Gerardo Hosp, Dept Clin Pathol, Immunohematol & Transfus Therapeut Aphaeresis Uni, Milan, Italy
关键词:
Extracorporeal photochemotherapy;
Regulatory T cells;
GvHD;
Th-17;
VERSUS-HOST-DISEASE;
MECHANISMS;
EXPRESSION;
D O I:
10.1097/TP.0b013e3181a27a5d
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Background. Immune mechanisms of extracorporeal photochernotherapy (ECP) in refractory/resistant graft-versus-host disease (GvHD) are complex. We have previously analyzed the role of CD4(+)CD25(+)Foxp3(+) regulatory T cells (T-regs). Methods. In the current study, we have enlarged the size of the population (n=27; chronic GvHD=18, acute GvHD=9) for a median follow-up of 24 months. T-regs were monitored for CD4, CD25, glucocorticoid-induced tumor necrosis factor receptor (GITR), CD62L, CCR7, Foxp3, and STAT-5. Immune analysis by interleukin (IL)-17 Elispot was carried out on circulating T-helper CD4(+) cells secreting IL-17, a subset of T cells considered relevant in the pathogenesis of GvHD. Results. We confirm that ECP is accompanied by a significant increase of CD4(+)CD25(+)Foxp3(+)GITR(+)CD62L(+)CCR7(+) T-regs. Sorted T-regs show augmented phosphorylation of STAT-5. Only ECP-responding patients demonstrate a raise of circulating T-regs, being mostly affected by chronic GvHD. Moreover, this phenomenon corresponds to a diminished secretion of IL-17. Discussion. In conclusion, our study shows that T-regs represent important immune mediators of the clinical benefits of ECP in patients affected by GvHD.
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页码:1422 / 1425
页数:4
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Zorn, Emmanuel
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Nelson, Erik A.
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Mohseni, Mehrdad
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Porcheray, Fabrice
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Kim, Haesook
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Litsa, Despina
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Bellucci, Roberto
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Raderschall, Elke
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Canning, Christine
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Soiffer, Robert J.
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Frank, David A.
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Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Hematol Maligancies, Boston, MA 02115 USA

Ritz, Jerome
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