Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

被引：262
作者：
Duda, JE
Giasson, BI
Mabon, ME
Lee, VMY
Trojanowski, JQ
机构：
[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA
[2] Philadelphia Vet Affairs Hosp, Parkinsons Dis Res Educ & Clin Ctr, Philadelphia, PA USA
来源：
ANNALS OF NEUROLOGY | 2002年 / 52卷 / 02期
关键词：
D O I：
10.1002/ana.10279
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.
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页码：205 / 210
页数：6
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