Analysis of factors that induce cysteine bonding state

被引:5
|
作者
Jahandideh, Samad [1 ]
Hoseini, Somayyeh [2 ]
Jahandideh, Mina [3 ]
Hoseini, Afsaneh [4 ]
Yazdi, Ali Salehzadeh [5 ]
机构
[1] Shiraz Univ Med Sci, Dept Med Phys, Shiraz, Iran
[2] Tabriz Univ Med Sci, Div Genet, Dept Biochem, Tabriz, Iran
[3] Vali E Asr Univ, Fac Sci, Dept Math, Rafsanjan, Iran
[4] Islamic Azad Univ Arak, Dept Comp Engn, Arak, Iran
[5] Univ Tehran, Dept Biochem & Biophys, Tehran, Iran
关键词
Cysteine bonding state; Sequence analysis; Singlet local propensity (SLP); Doublet local propensity (DLP); PREDICTION; PROTEINS;
D O I
10.1016/j.compbiomed.2009.01.006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Regarding the fact that the protein structure is principally encoded in its sequence, investigating the bonding state of cysteine has gained a great deal of attention due to its significance in the formation of protein structure. Due to lack of evident influence of free cysteines on the protein structure, it may be expected that only half-cystines convey encoded information. The results obtained from the analysis of amino acid distribution in proximity of both states of cysteines explicitly indicated that perquisite information for inducing cysteine bonding state is present even in the flanking amino acid sequences of free cysteines. (c) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:332 / 339
页数:8
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