Cytocompatibility and Antibacterial Properties of Capping Materials

被引：77

作者：

Poggio, Claudio ^{[1
]}

Arciola, Carla Renata ^{[2
]}

Beltrami, Riccardo ^{[3
]}

Monaco, Annachiara ^{[4
,5
]}

Dagna, Alberto ^{[1
]}

Lombardini, Marco ^{[1
]}

Visai, Livia ^{[4
,5
]}

机构：

[1] Univ Pavia, Policlin San Matteo, Dept Clin Surg Diagnost & Pediat Sci, I-27100 Pavia, Italy

[2] Univ Bologna, DIMES, Rizzoli Orthoped Inst, Res Unit Implant Infect, I-40136 Bologna, Italy

[3] Univ Pavia, Dept Brain & Behav Sci, I-27100 Pavia, Italy

[4] Univ Pavia, INSTM UdR, CIT, Dept Mol Med, I-27100 Pavia, Italy

[5] Salvatore Maugeri Fdn, IRCCS, Dept Occupat Med Ergon & Disabil, Lab Nanotechnol, I-27100 Pavia, Italy

来源：

SCIENTIFIC WORLD JOURNAL | 2014年

关键词：

MINERAL TRIOXIDE AGGREGATE; CALCIUM HYDROXIDE; MTA; DENTIN; CELLS; APOPTOSIS; ADHESIVE; BARRIER; DIFFERENTIATION; PROLIFERATION;

D O I：

10.1155/2014/181945

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study was to evaluate and compare the antimicrobial activity and cytocompatibility of six different pulp-capping materials: Dycal (Dentsply), Calcicur (Voco), Calcimol LC (Voco), TheraCal LC (Bisco), MTA Angelus (Angelus), and Biodentine (Septodont). To evaluate antimicrobial activity, materials were challenged in vitro with Streptococcus mutans, Streptococcus salivarius, and Streptococcus sanguis in the agar disc diffusion test. Cytocompatibility of the assayed materials towards rat MDPC-23 cells was evaluated at different times by both MTT and apoptosis assays. Results significantly differed among the different materials tested. Both bacterial growth inhibition halos and cytocompatibility performances were significantly different among materials with different composition. MTA-based products showed lower cytotoxicity and valuable antibacterial activity, different from calcium hydroxide-based materials, which exhibited not only higher antibacterial activity but also higher cytotoxicity.

引用

页数：10

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