The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex

被引：50
作者：
Bubeck, Doryen [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
来源：
BIOCHEMISTRY | 2014年 / 53卷 / 12期
关键词：
PORE FORMATION; BINDING-SITE; HUMAN CD59; PERFRINGOLYSIN-O; STRUCTURAL BASIS; CRYSTAL-STRUCTURE; PROVIDE INSIGHTS; PROTEIN C8-ALPHA; 8TH COMPONENT; MACPF DOMAIN;
D O I：
10.1021/bi500157z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The complement terminal pathway clears pathogens by generating cytotoxic membrane attack complex (MAC) pores on target cells. For more than 40 years, biochemical and cellular assays have been used to characterize the lytic nature of the MAC and to define its protein composition. Although models for pore formation have been inferred from structures of bacterial cytolysins, it was only recently that we were able to visualize how complement components come together during MAC assembly. This review highlights structural analyses of terminal pathway complexes to explore molecular mechanisms underlying MAC formation.
引用
收藏
页码：1908 / 1915
页数：8
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