Risk of Stroke in Patients with Rheumatism: A Nationwide Longitudinal Population-based Study

被引:46
作者
Liou, Tsan-Hon [1 ,2 ]
Huang, Shih-Wei [1 ]
Lin, Jia-Wei [3 ,4 ]
Chang, Yu-Sheng [5 ]
Wu, Chin-Wen [1 ]
Lin, Hui-Wen [6 ,7 ]
机构
[1] Taipei Med Univ, Shuang Ho Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan
[2] Taipei Med Univ, Grad Inst Injury Prevent & Control, Taipei, Taiwan
[3] Taipei Med Univ, Shuang Ho Hosp, Dept Neurosurg, Taipei, Taiwan
[4] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan
[5] Taipei Med Univ, Shuang Ho Hosp, Dept Rheumatol, Taipei, Taiwan
[6] Soochow Univ, Dept Math, Taipei, Taiwan
[7] Taipei Med Univ, Wan Fang Hosp, Evidence Based Med Ctr, Taipei, Taiwan
来源
SCIENTIFIC REPORTS | 2014年 / 4卷
关键词
SYSTEMIC-LUPUS-ERYTHEMATOSUS; ISCHEMIC-STROKE; CARDIOVASCULAR EVENTS; MYOCARDIAL-INFARCTION; DISEASE; COHORT; ATHEROSCLEROSIS; ARTHRITIS; HOSPITALIZATION; POLYMORPHISMS;
D O I
10.1038/srep05110
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The aim of this study was to investigate rheumatoid arthritis (RA), and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study investigated patients with a recorded diagnosis of RA (N = 6114), and SLE (N = 621) between January 1, 2004, and December 31, 2007, with age-matched controls (1:4) (for RA, N = 24456; SLE, N = 2484). We used Cox proportional-hazard regressions to evaluate the hazard ratios (HRs) after adjusting confounding factors. Our study found 383 of 6114 RA patients, experienced stroke during the 20267 person-year follow-up period. The adjusted HR of stroke for RA patients was 1.24 (95% CI, 1.11 to 1.39), and for SLE patients was 1.88 (95% CI, 1.08 to 3.27). When steroid was added as additional confounding factor, the adjusted HR of ischemic stroke for RA patients was 1.32 (95% CI, 1.15 to 1.50), and for SLE patients was 1.31 (95% CI, 0.51 to 3.34). In conclusion, the rheumatic diseases of RA, and SLE are all risk factors for stroke. After controlled the effect of steroid prescription, RA is risk factor for ischemic stroke.
引用
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页数:6
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