DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET-Optical Imaging

被引：28

作者：

Brizet, Bertrand ^{[1
,2
]}

Goncalves, Victor ^{[1
]}

Bernhard, Claire ^{[1
]}

Harvey, Pierre D. ^{[2
]}

Denat, Franck ^{[1
]}

Goze, Christine ^{[1
]}

机构：

[1] Univ Bourgogne, Inst Chim Mol, UMR 6302, F-21078 Dijon, France

[2] Univ Sherbrooke, Dept Chim, Sherbrooke, PQ J1K 2R1, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 40期

基金：

加拿大自然科学与工程研究理事会;

关键词：

alkynes; click chemistry; fluorine; imaging agents; luminescence; radiochemistry; EMISSION-TOMOGRAPHY; DYES; CHEMISTRY; AGENTS; PEPTIDES; BOMBESIN; YIELD;

D O I：

10.1002/chem.201402379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several new boron dipyrromethene/N,N-dimethylaminopyridine (BODIPY-DMAP) assemblies were synthesized as precursors for bimodal imaging probes (optical imaging, I/positron emission tomography, PET). The photophysical properties of the new compounds were also studied. The first proof-of-concept was obtained with the preparation of several new BODIPY-labeled bombesins and evaluation of the affinity for bombesin receptors by using a competition binding assay. Fluorination reactions were investigated on DMAP-BODIPY precursors as well as on DMAP-BODIPY-labeled bombesins. Chemical modifications on the BODIPY core were also performed to obtain luminescent dyes emitting in the therapeutic window (650-900 nm), suitable for in vivo imaging, making these compounds promising precursors for PET/optical dual-modality imaging agents.

引用

页码：12933 / 12944

页数：12

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