Historical epidemiology of hepatitis C virus (HCV) in selected countries

被引：216

作者：

Bruggmann, P. ^{[1
]}

Berg, T. ^{[2
]}

Ovrehus, A. L. H. ^{[3
]}

Moreno, C. ^{[4
]}

Brandao Mello, C. E. ^{[5
]}

Roudot-Thoraval, F. ^{[6
]}

Marinho, R. T. ^{[7
]}

Sherman, M. ^{[8
]}

Ryder, S. D. ^{[9
,10
]}

Sperl, J. ^{[11
]}

Akarca, U. ^{[12
]}

Balik, I. ^{[13
]}

Bihl, F. ^{[14
]}

Bilodeau, M. ^{[15
]}

Blasco, A. J. ^{[16
]}

Buti, M. ^{[17
]}

Calinas, F. ^{[18
]}

Calleja, J. L. ^{[19
]}

Cheinquer, H. ^{[20
]}

Christensen, P. B. ^{[3
]}

Clausen, M. ^{[21
]}

Coelho, H. S. M. ^{[22
]}

Cornberg, M. ^{[23
,24
]}

Cramp, M. E. ^{[25
]}

Dore, G. J. ^{[26
]}

Doss, W. ^{[27
]}

Duberg, A. S. ^{[28
,29
]}

El-Sayed, M. H. ^{[30
]}

Ergor, G. ^{[31
]}

Esmat, G. ^{[27
]}

Estes, C. ^{[32
]}

Falconer, K. ^{[33
]}

Felix, J. ^{[34
]}

Ferraz, M. L. G. ^{[35
]}

Ferreira, P. R. ^{[36
]}

Frankova, S. ^{[11
]}

Garcia-Samaniego, J. ^{[37
]}

Gerstoft, J. ^{[38
]}

Giria, J. A. ^{[39
]}

Goncales, F. L., Jr. ^{[40
]}

Gower, E. ^{[32
]}

Gschwantler, M. ^{[41
]}

Guimaraes Pessoa, M. ^{[42
]}

Hezode, C. ^{[43
]}

Hofer, H. ^{[44
]}

Husa, P. ^{[45
]}

Idilman, R. ^{[46
]}

Kaberg, M. ^{[33
]}

Kaita, K. D. E. ^{[47
,48
]}

Kautz, A. ^{[49
]}

机构：

[1] Arud Ctr Addict Med, CH-8005 Zurich, Switzerland

[2] Univ Leipzig, D-04109 Leipzig, Germany

[3] Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark

[4] Univ Libre Bruxelles, Erasme Univ Hosp, Brussels, Belgium

[5] Univ Fed Rio de Janeiro, Dept Gastroenterol, Rio De Janeiro, Brazil

[6] Hop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France

[7] Hosp Santa Maria, Ctr Hosp Lisboa Norte, Dept Gastroenterol, Lisbon, Portugal

[8] Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada

[9] Nottingham Univ Hosp NHS Trust, Nottingham, England

[10] Biomed Res Unit, Nottingham, England

[11] Inst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic

[12] Ege Univ, Izmir, Turkey

[13] Ankara Univ, TR-06100 Ankara, Turkey

[14] Osped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland

[15] Univ Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada

[16] Adv Tech Hlth Serv Res TAISS, Madrid, Spain

[17] Hosp Valle De Hebron, CIBERehd, Barcelona, Spain

[18] Hosp Santo Antonio Capuchos, Dept Gastroenterol, Ctr Hosp Lisboa Cent, Lisbon, Portugal

[19] Hosp Puerta Hierro, Madrid, Spain

[20] Univ Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil

[21] Region Hosp Hovedstaden, Region Hovedstaden, Denmark

[22] Univ Fed Rio de Janeiro, Dept Clin Med, Rio De Janeiro, Brazil

[23] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany

[24] German Liver Fdn, Hannover, Germany

[25] Univ Plymouth, Peninsula Schools Med & Dent, Plymouth PL4 8AA, Devon, England

[26] Univ New S Wales, Kirby Inst, Sydney, NSW, Australia

[27] Cairo Univ, Cairo, Egypt

[28] Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden

[29] Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden

[30] Ain Shams Univ, Cairo, Egypt

[31] Dokuz Eylul Univ, Izmir, Turkey

[32] Ctr Dis Anal CDA, Louisville, CO USA

[33] Karolinska Inst, Infect Dis Unit, Dept Med Huddinge, Stockholm, Sweden

[34] Exigo Consultores, Alhos Vedros, Portugal

[35] Univ Fed Sao Paulo, Div Gastroenterol, Sao Paulo, Brazil

[36] Univ Fed Sao Paulo, Div Infect Dis, Sao Paulo, Brazil

[37] Hosp Carlos III, CIBERehd, Madrid, Spain

[38] Univ Copenhagen, Copenhagen, Denmark

[39] Direccao Geral Saude, Lisbon, Portugal

[40] Univ Estadual Campinas, Fac Ciencias Med, UNICAMP,Dept Clin Med, Grp Estudo Hepatites,Disciplina Doencas Infeccios, Sao Paulo, Brazil

[41] Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria

[42] Univ Sao Paulo, Sch Med, Div Gastroenterol & Hepatol, Sao Paulo, Brazil

[43] Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France

[44] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria

[45] Masaryk Univ, Univ Hosp Brno, Clin Infect Dis, Brno, Czech Republic

[46] Ankara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey

[47] Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada

[48] Hlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada

[49] European Liver Patients Assoc, St Truiden, Belgium

[50] Istanbul Univ, Istanbul, Turkey

来源：

JOURNAL OF VIRAL HEPATITIS | 2014年 / 21卷

关键词：

treatment; mortality; diagnosis; incidence; HCV; epidemiology; prevalence; hepatitis C; disease burden; INJECTING DRUG-USERS; BLACK-SEA REGION; GENOTYPE DISTRIBUTION; HEPATOCELLULAR-CARCINOMA; HIGH PREVALENCE; BLOOD-DONORS; RISK-FACTORS; ELEVATED AMINOTRANSFERASES; ORTHOPEDIC-SURGERY; GENERAL-POPULATION;

D O I：

10.1111/jvh.12247

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. For some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. The largest viremic populations were in Egypt, with 6358000 cases in 2008 and Brazil with 2106000 cases in 2007. The age distribution of cases differed between countries. In most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level.

引用

页码：5 / 33

页数：29

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