Metallo-Supramolecular Nanogels for Intracellular pH-Responsive Drug Release

被引：11
|
作者：
Yao, Xuemei [1 ]
Chen, Li [1 ]
Chen, Xiaofei [1 ]
He, Chaoliang [2 ]
Zhang, Jingping [1 ]
Chen, Xuesi [2 ]
机构：
[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2014年 / 35卷 / 19期
基金：
中国国家自然科学基金;
关键词：
biocompatibility; drug delivery; metallo-supromolecular nanogels; pH responsiveness; DELIVERY PLATFORMS; MICELLES; NANOPARTICLES; COPOLYMER; POLYMERS; CHEMISTRY; VESICLES; SYSTEMS; CELLS; WATER;
D O I：
10.1002/marc.201400291
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A simple process is developed to fabricate metallo-supramolecular nanogels (MSNs) by the metallo-supramolecular-coordinated interaction between histidine and iron-meso-tetraphenylporphin. MSNs are composed of histidine-modified dextran (DH) and iron-meso-tetraphenylporphin (Fe-Por) and exhibit excellent biocompatibility and stability. MSNs show pH responsiveness in the intracellular mildly acidic environment, which has great potential for acid-triggered drug release delivery. In vitro drug release profiles demonstrate that the pH-dependent disassembly of MSNs to histidine and Por results in a quicker release rate of loaded-DOX at pH 5.3, while at pH 7.4 MSNs could hinder the release of loaded-DOX due to the enhanced stability of MSNs.
引用
收藏
页码：1697 / 1705
页数：9
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