Is There a Role for 5-HT3 Receptor Antagonists in the Treatment of Opioid-Induced Pruritus?

被引：3

作者：

Rashid, Saima ^{[1
]}

Trivedi, Disha D. ^{[2
]}

Al-Shathir, Mudher ^{[3
]}

Moulton, Marie ^{[1
]}

Baumrucker, Steven J. ^{[4
]}

机构：

[1] Mercy Hlth, Dept Pulm & Crit Care, Cincinnati, OH USA

[2] Fawcett Mem Hosp, Port Charlotte, FL USA

[3] Mercy Hlth, Dept Pulm & Crit Care, Cincinnati, OH USA

[4] Wellmont Hlth Syst, Hosp & Palliat Med, 4485 W Stone,Ste 200, Kingsport, TN 37660 USA

来源：

AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE | 2018年 / 35卷 / 04期

关键词：

pruritus; opioid; ondansetron; neuraxial; receptors; MORPHINE-INDUCED PRURITUS; PROPHYLACTIC INTRAVENOUS ONDANSETRON; PATIENT-CONTROLLED ANALGESIA; INTRATHECAL MORPHINE; CESAREAN DELIVERY; SPINAL OPIATES; DOSE NALOXONE; FENTANYL; ITCH; MANAGEMENT;

D O I：

10.1177/1049909117736062

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Pruritus is an unpleasant irritation symptom that can be related to various systemic and dermatological conditions. Although underreported, pruritus is a common adverse event noted after use of opioid pain medications. This article reviews the current understanding of the mechanism of opioid-induced pruritus (OIP) and various pharmacological therapies. 5-Hydroxytryptamine 3 (5-HT3) receptor antagonists are potentially effective for treating OIP and may be a valuable treatment option if further controlled studies are encouraging.

引用

页码：740 / 744

页数：5

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