Leishmanicidal Triterpenes from Lantana camara

被引：29
作者：
Begum, Sabira [1 ]
Ayub, Anjum [1 ]
Zehra, Syeda Qamar [1 ]
Siddiqui, Bina Shaheen [1 ]
Choudhary, M. Iqbal [1 ,2 ]
Samreen [1 ]
机构：
[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan
[2] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah 21412, Saudi Arabia
来源：
CHEMISTRY & BIODIVERSITY | 2014年 / 11卷 / 05期
关键词：
Lantana camara; Triterpenoids; Lantaninilic acid; Lantoic acid; Leishmanicidal activity; Leishmania major; ACID; STEREOCHEMISTRY; CONSTITUENTS;
D O I：
10.1002/cbdv.201300151
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new natural triterpenes, lantaninilic acid and lantoic acid, along with the known triterpenes lantadene A, and oleanolic, ursolic, betulinic, lantanolic, and camaric acid, were obtained from the aerial parts of Lantana camara through bioassay-guided isolation, monitoring the in vitro antileishmanial activity against promastigotes of Leishmania major. Oleanolic acid (3), ursolic acid (4), lantadene A (5), and lantanilic acid (7) showed significant leishmanicidal activities with IC50 values of 53.0, 12.4, 20.4, and 21.3M, respectively. The IC50 value of ursolic acid (4; 12.4M) was found to be comparable with that of the standard drugs, pentamidine (IC50 15.0M) and amphotericin B (IC50 0.31M). The in vitro activities of L. camara and its constituents against promastigotes of Leishmania major are reported here for the first time.
引用
收藏
页码：709 / 718
页数：10
相关论文
共 30 条
  • [1] PHYTOCHEMICAL STUDY OF LANTANA-CAMARA - TERPENES AND LACTONES .2.
    AHMED, ZF
    WASSEL, GM
    ELSAYYAD, SM
    ELMOGHAZ.AM
    [J]. PLANTA MEDICA, 1972, 22 (01) : 34 - &
  • [2] The leishmaniases as emerging and reemerging zoonoses
    Ashford, RW
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2000, 30 (12-13) : 1269 - 1281
  • [3] Discovery of leishmanicidal agents from medicinal plants
    Atta-ur-Rahman
    Samreen
    Atia-tul-Wahab
    Choudhary, M. Iqbal
    [J]. PURE AND APPLIED CHEMISTRY, 2008, 80 (08) : 1783 - 1790
  • [4] BARTON DHR, 1956, TRITERPENOIDS 23, P4160
  • [5] BARUA AK, 1985, J INDIAN CHEM SOC, V62, P298
  • [6] STRUCTURE AND STEREOCHEMISTRY OF LANTANILIC ACID, BETA,BETA-DIMETHYLACRYLOYL ESTER OF LANTANINILIC ACID, ISOLATED FROM LANTANA-CAMARA
    BARUA, AK
    CHAKRABARTI, P
    CHOWDHURY, MK
    BASAK, A
    BASU, K
    [J]. PHYTOCHEMISTRY, 1976, 15 (06) : 987 - 989
  • [7] Antimycobacterial activity of flavonoids from Lantana camara Linn
    Begum, S.
    Wahab, A.
    Siddiqui, B. S.
    [J]. NATURAL PRODUCT RESEARCH, 2008, 22 (06) : 467 - 470
  • [8] Nematicidal constituents of the aerial parts of Lantana camara
    Begum, S
    Wahab, A
    Siddiqui, BS
    Qamar, F
    [J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (06): : 765 - 767
  • [9] The increase in risk factors for leishmaniasis worldwide
    Desjeux, P
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2001, 95 (03) : 239 - 243
  • [10] Lantana camara L. (Verbenaceae)
    Ghisalberti, EL
    [J]. FITOTERAPIA, 2000, 71 (05) : 467 - 486
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