In Vivo Evaluation in Monkey Brain of the COX-1 and COX-2 Selective Positron Emission Tomographic Radioligands [11C]PS13 and [11C]MC1

被引：0
|
作者：
Shrestha, Stal [1 ]
Cortes, Michelle [1 ]
Singh, Prachi [1 ]
Jenko, Kimberly [1 ]
Gladding, Robert [1 ]
Morse, Cheryl [1 ]
Zoghbi, Sami [1 ]
Fujita, Masahiro [1 ]
Pike, Victor [1 ]
Innis, Robert [1 ]
机构：
[1] NIMH, Bethesda, MD 20892 USA
来源：
NEUROPSYCHOPHARMACOLOGY | 2015年 / 40卷
关键词：
Positron emission tomography; Inflammatory Markers; COX-1;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
M54
引用
收藏
页码：S139 / S140
页数：2
相关论文
共 50 条
  • [1] [11C]PS13 shows pharmacologically selective binding to cyclooxygenase-1 (COX-1) in the human brain
    Ghazanfari, Nafiseh
    Norgaard, Martin
    Liow, Jeih-San
    Cureton, Raven
    Hong, Jinsoo
    Santamaria, Jose Angel Montero
    Shetty, H. Umesha
    Galassi, Anthony
    Wighton, Paul
    Greve, Douglas X. Douglas
    Zoghbi, Sami
    Pike, Victor
    Innis, Robert
    Fregonara, Paolo Zanotti
    JOURNAL OF NUCLEAR MEDICINE, 2024, 65
  • [2] [11C]PS13 shows high specific and displaceable binding to COX-1 enzyme inthe human brain
    Ghazanfari, Nafiseh
    Kim, Min-Jeong
    Knoer, Carson
    Hong, Jinsoo
    Ahmadi, Fatemeh
    Santamaria, Jose Angel Montero
    Zoghbi, Sami
    Liow, Jeih-San
    Pike, Victor
    Innis, Robert
    Fregonara, Paolo Zanotti
    JOURNAL OF NUCLEAR MEDICINE, 2023, 64
  • [3] First-in-human evaluations of [11C]PS13 for imaging cyclooxygenase-1 and [11C]MC1 for imaging cyclooxygenase-2
    Kim, Min-Jeong
    Anaya, Fernanda Juarez
    Lee, Jae-Hoon
    Hong, Jinsoo
    Miller, William
    Telu, Sanjay
    Morse, Cheryl
    Singh, Prachi
    Cortes-Salva, Michelle Y.
    Henry, Katharine
    Ruiz-Perdomo, Yanira
    Santamaria, Jose A. Montero
    Liow, Jeih-San
    Zoghbi, Sami S.
    Fujita, Masahiro
    Katz, James D.
    Pike, Victor W.
    Innis, Robert B.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2021, 41 (1_SUPPL): : 239 - 240
  • [4] A novel PET radioligand, [11C]PS13, successfully images COX-1, a potential biomarker for neuroinflammation.
    Shrestha, Stal
    Singh, Prachi
    Eldridge, Mark
    Cortes, Michelle
    Gladding, Robert
    Morse, Cheryl
    Zoghbi, Sami
    Fujita, Masahiro
    Liow, Jeih-San
    Pike, Victor
    JOURNAL OF NUCLEAR MEDICINE, 2016, 57
  • [5] Repurposing [11C]MC1 for imaging COX-2 in colorectal cancer xenograft mouse models
    Boyle, Amanda
    Tong, Junchao
    Zoghbi, Sami
    Pike, Victor
    Innis, Robert
    Vasdev, Neil
    JOURNAL OF NUCLEAR MEDICINE, 2021, 62
  • [6] In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons
    Kumar, J. S. Dileep
    Zanderigo, Francesca
    Prabhakaran, Jaya
    Rubin-Falcone, Harry
    Parsey, Ramin, V
    Mann, J. John
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (23-24) : 3592 - 3595
  • [7] Radiosynthesis and evaluation of [11C]FK881 as a PET radioligand for imaging brain COX-1 in monkey
    Singh, Prachi
    Cortes, Michelle
    Morse, Cheryl
    Jenko, Kimberly
    Shrestha, Saurav
    Gladding, Robert
    Fujita, Masahiro
    Innis, Robert B.
    Pike, Victor W.
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2015, 58 : S55 - S55
  • [8] [11C]MC1 has adequate sensitivity to measure low density cyclooxygenase 2 (COX-2) in healthy human brain
    Yan, Xuefeng
    Zhang, Andrea
    Zoghbi, Sami S.
    Liow, Jeih-San
    Morse, Cheryl
    Kim, Min-Jeong
    Araneta, Maria Ferraris
    Santamaria, Jose A. Montero
    Manly, Lester
    Jenkins, Madeline
    Van Buskirk, Maia
    Kenou, Bruny
    Rubovits, Sara
    Miller, William
    Pike, Victor W.
    Zanotti-Fregonara, Paolo
    Innis, Robert B.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2021, 41 (1_SUPPL): : 140 - 140
  • [9] 3-Substituted 1,5-Diary1-1H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging
    Shrestha, Stal
    Singh, Prachi
    Cortes-Salva, Michelle Y.
    Jenko, Kimberly J.
    Ikawa, Masamichi
    Kim, Min-Jeong
    Kobayashi, Masato
    Morse, Cheryl L.
    Gladding, Robert L.
    Zoghbi, Sami S.
    Fujita, Masahiro
    Innis, Robert B.
    Pike, Victor W.
    ACS CHEMICAL NEUROSCIENCE, 2018, 9 (11): : 2620 - 2627
  • [10] Evaluation of [11C]TMI as a COX-2 selective PET tracer in baboon
    Kumar, Dileep
    Zanderigo, Francesca
    Prabhakaran, Jaya
    Rubin-Falcone, Harry
    Parsey, Ramin
    Mann, J. John
    JOURNAL OF NUCLEAR MEDICINE, 2018, 59
12345