EVIDENCE-BASED GUIDELINES MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-establishing disease prognosis and monitoring patients

被引:380
作者
Wattjes, Mike P. [1 ]
Rovira, Alex [2 ]
Miller, David [4 ]
Yousry, Tarek A. [5 ]
Sormani, Maria P. [6 ]
de Stefano, Nicola [7 ]
Tintore, Mar [3 ]
Auger, Cristina [2 ]
Tur, Carmen [3 ]
Filippi, Massimo [8 ]
Rocca, Maria A. [8 ]
Fazekas, Franz [9 ]
Kappos, Ludwig [10 ]
Polman, Chris [1 ]
Barkhof, Frederik [1 ]
Montalban, Xavier [2 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med & Neurol, MS Ctr Amsterdam, NL-1081 HV Amsterdam, Netherlands
[2] Autonomous Univ Barcelona, Hosp Vall dHebron, Cemcat, Magnet Resonance Unit, E-08193 Barcelona, Spain
[3] Autonomous Univ Barcelona, Hosp Vall dHebron, Cemcat, Neurol Neuroimmunol Unit, E-08193 Barcelona, Spain
[4] UCL, Inst Neurol, NMR Res Unit, Queen Sq MS Ctr, London WC1E 6BT, England
[5] UCL, Inst Neurol, Lysholm Dept Neuroradiol, UCLH Natl Hosp Neurol & Neurosurg, London WC1E 6BT, England
[6] Univ Genoa, Dept Hlth Sci, Biostat Unit, I-16126 Genoa, Italy
[7] Univ Siena, Dept Neurol & Behav Sci, I-53100 Siena, Italy
[8] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Inst Expt Neurol, Neuroimaging Res Unit,Div Neurosci, Milan, Italy
[9] Med Univ Graz, Dept Neurol, Graz, Austria
[10] Univ Basel, Dept Neurol, CH-4003 Basel, Switzerland
关键词
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; MAGNETIZATION-TRANSFER RATIO; LONG-TERM DISABILITY; SPINAL-CORD LESIONS; BRAIN ATROPHY; FOLLOW-UP; GLATIRAMER ACETATE; INTERFERON-BETA; DIAGNOSTIC-CRITERIA; COGNITIVE IMPAIRMENT;
D O I
10.1038/nrneurol.2015.157
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The role of MRI in the assessment of multiple sclerosis (MS) goes far beyond the diagnostic process. MRI techniques can be used as regular monitoring to help stage patients with MS and measure disease progression. MRI can also be used to measure lesion burden, thus providing useful information for the prediction of long-term disability. With the introduction of a new generation of immunomodulatory and/or immunosuppressive drugs for the treatment of MS, MRI also makes an important contribution to the monitoring of treatment, and can be used to determine baseline tissue damage and detect subsequent repair. This use of MRI can help predict treatment response and assess the efficacy and safety of new therapies. In the second part of the MAGNIMS (Magnetic Resonance Imaging in MS) network's guidelines on the use of MRI in MS, we focus on the implementation of this technique in prognostic and monitoring tasks. We present recommendations on how and when to use MRI for disease monitoring, and discuss some promising MRI approaches that may be introduced into clinical practice in the near future.
引用
收藏
页码:597 / 606
页数:10
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