Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity

被引：63

作者：

Gu, Jun ^{[1
,2
]}

Hu, Wei ^{[2
]}

Zhang, Da-dong ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Cardiol, Sch Med, Shanghai 200030, Peoples R China

[2] Fudan Univ, Dept Cardiol, Shanghai Minhang Hosp, Shanghai 200433, Peoples R China

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2015年 / 19卷 / 10期

关键词：

doxorubicin; cardiotoxicity; resveratrol; ROS; apoptosis; autophagy; INDUCED CARDIOMYOCYTE APOPTOSIS; INDUCED TOXICITY; RAT HEARTS; AUTOPHAGY; DEATH; MICE; INHIBITION; PREVENTION; PATHWAY; INJURY;

D O I：

10.1111/jcmm.12633

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Doxorubicin is the mainstay of treatment for various haematological malignancies and solid tumours. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanism of doxorubicin-induced cardiotoxicity may involve various signalling pathways including free radical generation, peroxynitrite formation, calcium overloading, mitochondrial dysfunction and alteration in apoptosis and autophagy. Interestingly, the use of resveratrol in combination with doxorubicin has been reported to prevent cardiac toxicity as well as to exert a synergistic effect against tumour cells both invivo and invitro. Thus, the aim of this review is to summarize current knowledge and to elucidate the protective effect of resveratrol in doxorubicin-induced cardiotoxicity.

引用

页码：2324 / 2328

页数：5

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