Receptor trafficking and the plasticity of excitatory synapses

被引：245

作者：

Barry, MF ^{[1
]}

Ziff, EB ^{[1
]}

机构：

[1] NYU, Med Ctr, Dept Biochem, Howard Hughes Med Inst, New York, NY 10016 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(02)00329-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Newly discovered features of the trafficking of AMPA receptors to and from the postsynaptic membrane of excitatory synapses are now bringing the mechanisms of synaptic plasticity into focus. Recent advances, including the existence of slots, anchors, transport factors and pathways for activity-dependent control, have elucidated the role of the individual AMPA receptor subunits and their binding partners. The latest views describe how subunit type dictates the assembly of heteromeric receptors, and how these heteromers interact with the receptor trafficking machinery and synaptic anchorage factors. Moreover, phosphorylation may play an important role in receptor transport and synaptic turnover.

引用

页码：279 / 286

页数：8

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