Near-infrared fluorescent probes for the detection of glutathione and their application in the fluorescence imaging of living cells and tumor-bearing mice

被引：69

作者：

Lee, Dayoung ^{[1
]}

Jeong, Keunsoo ^{[2
]}

Luo, Xiao ^{[3
]}

Kim, Gayoung ^{[2
]}

Yang, Youjun ^{[3
]}

Chen, Xiaoqiang ^{[1
,4
]}

Kim, Sehoon ^{[2
]}

Yoon, Juyoung ^{[1
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nano Sci BK21, Seoul 120750, South Korea

[2] Korea Inst Sci & Technol, Ctr Theragnosis, Hwarangno 14 Gil 5, Seoul 136791, South Korea

[3] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Meilong Rd 130, Shanghai 200236, Peoples R China

[4] Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 17期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

HIGHLY SELECTIVE DETECTION; AQUEOUS-SOLUTION; RECENT PROGRESS; IN-VIVO; CYSTEINE; GSH; SENSOR; CHEMOSENSORS; HOMOCYSTEINE; ENSEMBLE;

D O I：

10.1039/c7tb01560g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Two new cyanine-based fluorescent probes 1 and 2 have been developed. Probe 1 bears two cyanine units in a single molecule, and probe 2 contains a bis(trifluoromethyl)benzenethiol moiety. Both are non-fluorescent. The addition of intracellular glutathione (GSH) significantly enhanced the NIR fluorescence of the two probes. Both probes were used to image varying amounts of GSH in living cells. In tumor bearing mice, the in vivo fluorescence intensity of both probes was higher in tumors, where GSH is overexpressed, than in normal tissues. These results suggest that these new fluorogenic probes have potential for GSH-targeting diagnostic imaging.

引用

页码：2541 / 2546

页数：6

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