Histone deacetylases in cardiac fibrosis: Current perspectives for therapy

被引：48

作者：

Tao, Hui ^{[1
,2
]}

Shi, Kai-Hu ^{[1
,2
]}

Yang, Jing-Jing ^{[3
,4
]}

Huang, Cheng ^{[3
]}

Zhan, Hong-Ying ^{[1
,2
]}

Li, Jun ^{[3
]}

机构：

[1] Anhui Med Univ, Hosp 2, Dept Cardiothorac Surg, Hefei 230601, Peoples R China

[2] Anhui Med Univ, Cardiovasc Res Ctr, Hefei 230601, Peoples R China

[3] Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China

[4] Anhui Med Univ, Hosp 2, Dept Pharmacol, Hefei 230601, Peoples R China

来源：

CELLULAR SIGNALLING | 2014年 / 26卷 / 03期

基金：

美国国家科学基金会;

关键词：

Histone deacetylase; Cardiac fibrosis; Epigenetic; Histone deacetylation; Fibroblast; Proliferation; PROMOTES CELL-PROLIFERATION; PROTEIN-KINASE D1; GENE-EXPRESSION; GROWTH-FACTOR; HEART-FAILURE; TRANSCRIPTIONAL REPRESSION; DIFFERENTIAL REGULATION; ANTIFIBROTIC ACTIVITY; FIBROBLAST MIGRATION; NUCLEAR EXPORT;

D O I：

10.1016/j.cellsig.2013.11.037

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases. The molecular mechanisms of cardiac fibrosis are unknown. Histone deacetylases (HDACs) are enzymes that balance the acetylation activities of histone acetyltransferases on chromatin remodeling and play essential roles in regulating gene transcription. In recent years, the role of HDACs in cardiac fibrosis initiation and progression, as well as the therapeutic effects of HDAC inhibitors, has been well studied. Moreover, numerous studies indicated that HDAC activity is associated with the development and progression of cardiac fibrosis. In this review, the innovative aspects of HDACs are discussed, with respect to biogenesis, their role in cardiac fibrosis. Furthermore, the potential applications of HDAC inhibitors in the treatment of cardiac fibrosis associated with fibroblast activation and proliferation. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：521 / 527

页数：7

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