The role of structural and functional insular cortex abnormalities in body perception disturbance in schizophrenia

Objectives. - The present study focuses on a review of scientific literature upon structural and functional abnormalities of the insular cortex found in schizophrenic patients in order to emphasize links between the pathophysiology of this brain region and the symptomatology of schizophrenia. Methods. - From a review based upon journal articles published since 2002 and indexed into the Pubmed data base, we first studied the main findings on the function of the insular cortex and its involvement in the perception and representation of the body states, as it is one of the main neural substrates for the interoception sense. Then, we highlighted various structural abnormalities found in schizophrenic patients in order to study links existing between dysfunctions in the insular cortex and an altered perception of body states and of self-awareness in schizophrenia. Eventually, we studied the links emphasized between functional abnormalities of insula in schizophrenia and a positive symptomatology, especially auditory hallucinations. Results. - The data in the neurobiological literature about abnormalities in the insular cortex in schizophrenia has demonstrated that insula dysfunctions could constitute one of the biological substrates of disorders of body perception in schizophrenia, and it could be a source of the alteration of the sense of self that is characteristic of this psychiatric pathology. Moreover, the importance of insula in processing interoceptive stimuli and their integration with exteroceptive stimuli could engender a problem in the discrimination between endogenic and exogenic stimuli, a problem that could thus be involved in the positive symptomatology of schizophrenia, such as auditory hallucinations and delusion. Conclusions. - Scientific knowledge in the role of the insula for the perception and representation of the body states shows that the insula has a key role for interoception. Functional abnormalities of the insular cortex in schizophrenia may lead to the conclusion that this area of the brain is one of the biological substrates for the disorders of body perception in schizophrenia, and also, mainly, one of the substrates for the disorders of self-awareness which depends, according to many authors, on the representation of the body states. Moreover, the role of the insula in integrating interoceptive and exteroceptive stimuli leads to the supposition that dysfunctions of the insula could result in a problem concerning the discrimination between endogenic and exogenic stimuli, and thus could create a positive symptomatology, mainly auditory hallucinations for schizophrenic patients. It needs to be noted that the links between the symptomatology of schizophrenia and the dysfunctions of the insular cortex are still in debate among researchers. Recent researches do not allow to conclude with accuracy of a systematic correlation between psychopathology of schizophrenia and functional abnormalities of the insula, although it seems obvious to find a link between these psychopathological and neurobiological phenomena. (C) 2021 L'Encephale, Paris.