Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N-acetylcysteine

被引：51
|
作者：
Shayani-Jam, Hasan [1 ]
Nematollahi, Davood [1 ]
机构：
[1] F Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Iran
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 03期
关键词：
P-BENZOQUINONE IMINE; INDUCED HEPATIC-NECROSIS; PEROXIDASE; MECHANISMS;
D O I：
10.1039/b916458h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrochemical oxidation of acetaminophen has been studied in the presence of glutathione and acetylcysteine. Our results indicate that N-acetyl-p-benzoquinone-imine (NAPQI) participates in a catalytic reaction with glutathione and N-acetylcysteine. Also, the observed homogeneous rate constants of the reaction of NAPQI with glutathione and acetylcysteine were estimated.
引用
收藏
页码：409 / 411
页数：3
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