SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF NOVEL PLATINUM(II) COMPLEXES CONTAINING SUBSTITUTED BENZIMIDAZOLE LIGANDS

被引：0

作者：

Nzeyimana, Abdoul ^{[1
]}

Utku, Semra ^{[1
]}

Acik, Leyla ^{[2
]}

Keskin, Ayten Celebi ^{[3
]}

机构：

[1] Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey

[2] Gazi Univ, Fac Sci, Dept Biol, TR-06500 Ankara, Turkey

[3] Kirikkale Univ, Fac Engn, Dept Bioengn, TR-71450 Kirikkale, Turkey

来源：

REVUE ROUMAINE DE CHIMIE | 2017年 / 62卷 / 03期

关键词：

benzimidazole; platinum complexes; synthesis; gel electrophoresis; cisplatin; CYTOTOXIC ACTIVITY; MOLECULAR-MECHANISMS; CISPLATIN; BINDING; 2-HYDROXYMETHYLBENZIMIDAZOLE; DERIVATIVES; RESISTANCE; CATALYST; MCF-7;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Eight novel Pt(II) complexes corresponding to the following general formula [PtCl2(L-1-L-4)(2)] (C1 -C4) and [PtI2((L1-L4))(2)] (C5-C8) in which 5(6)-chloro/or-methyl-2-H/or-methylbenzimidazole (L-1-L-4) played the key role as carrier ligands were synthesized and characterized by elemental analysis, IR and H-1 NMR. Considering leaving group functions, the anionic ligand iodido and chloro were utilized with the purpose of studying the interaction between the synthesized complexes and pBR322 plasmid DNA by using cisplatin as positive control throughout the Agarose Gel Electrophoresis method. Therefore, looking after plasmid DNA interacting outcomes, synthesized complexes modified the tertiary structure of pBR322 plasmid DNA, and the results showed that the complex C2 ([PtCl2(L-2)(2)]) was highly active compound regarding to all synthesized complexes.

引用

页码：227 / 236

页数：10

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