Clinical isolates of Enterobacteriaceae producing extended-spectrum β-lactamases:: Prevalence of CTX-M-3 at a hospital in China

被引：69
作者：
Wang, H
Kelkar, S
Wu, WY
Chen, MJ [1 ]
Quinn, JP
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
[2] Univ Illinois, Dept Med, Chicago, IL 60612 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 02期
关键词：
D O I：
10.1128/AAC.47.2.790-793.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The prevalence of extended-spectrum beta-lactamase-producing strains was demonstrated in 5 of 44 (11.4%) Escherichia coli, 17 of 43 (39.5%) Klebsiella pneumoniae, 3 of 50 (6.0%) Enterobacter cloacae, and 2 of 25 (8.0%) Citrobacter freundii strains at a teaching hospital in China. Nineteen of these 27 strains expressed CTX-M-3 beta-lactamase (pI 8.6). A subset of the clinical isolates expressing the CTX-M-3 enzyme, tested by pulsed-field gel electrophoresis, revealed multiple clones. Five isolates expressed a novel enzyme, SHV-43 (pI 8.0), which had two substitutions (Leu113Phe and Thr149Ser) compared with SHV-1.
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收藏
页码：790 / 793
页数：4
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