Entry of viruses through the epithelial barrier: Pathogenic trickery

被引：148

作者：

Bomsel, M ^{[1
]}

Alfsen, A ^{[1
]}

机构：

[1] Univ Paris 05, INSERM, CNRS,Lab Mucosal Entry HIV & Mucosal Immun, Inst Cochin,Dept Biol Cellulaire, F-75014 Paris, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1038/nrm1005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mucosal surfaces - such as the lining of the gut or the reproductive tract - are the main point of entry for viruses into the body. As such, almost all viruses interact with epithelial cells, and make use of the normal epithelial signalling and trafficking pathways of the host cell. In addition to protein receptors, carbohydrate chains of proteoglycans and epithelial-membrane glycosphingolipids have emerged as a new class of receptors for viral attachment to the host cell.

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页码：57 / 68

页数：12

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