A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

被引：99

作者：

Khan, Nadeem Ghani ^{[1
]}

Correia, Jacinta ^{[1
]}

Adiga, Divya ^{[1
]}

Rai, Padmalatha Satwadi ^{[2
]}

Dsouza, Herman Sunil ^{[3
]}

Chakrabarty, Sanjiban ^{[1
,4
]}

Kabekkodu, Shama Prasada ^{[1
,4
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Sch Life Sci, Dept Cell & Mol Biol, Manipal 576104, Karnataka, India

[2] Manipal Acad Higher Educ, Manipal Sch Life Sci, Dept Biotechnol, Manipal 576104, Karnataka, India

[3] Manipal Acad Higher Educ, Manipal Sch Life Sci, Dept Radiat Biol & Toxicol, Manipal 576104, Karnataka, India

[4] Manipal Acad Higher Educ, Ctr DNA Repair & Genome Stabil CDRGS, Manipal 576104, Karnataka, India

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2021年 / 28卷 / 16期

关键词：

Bisphenol A; Endocrine disruptor; Carcinogen; Environmental toxicant; Human cancer; OVARIAN-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; LONG-TERM EXPOSURE; GENE-EXPRESSION; UP-REGULATION; STEM-CELLS; PERINATAL EXPOSURE; SIGNALING PATHWAY; DNA METHYLATION; MAMMARY-GLAND;

D O I：

10.1007/s11356-021-13071-w

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bisphenol A [BPA; (CH3)(2)C(C6H4OH)(2)] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.

引用

页码：19643 / 19663

页数：21

共 140 条

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