Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids

被引：8

作者：

Neochoritis, Constantinos G. ^{[1
,2
]}

Zarganes-Tzitzikas, Tryfon ^{[1
]}

Novotna, Michaela ^{[1
]}

Mitrikova, Tatiana ^{[1
]}

Wang, Zefeng ^{[1
]}

Kurpiewska, Katarzyna ^{[3
]}

Kalinowska-Tluscik, Justyna ^{[3
]}

Domling, Alexander ^{[1
]}

机构：

[1] Univ Groningen, Dept Pharm, Drug Design Grp, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands

[2] Univ Crete, Dept Chem, Iraklion 70013, Crete, Greece

[3] Jagiellonian Univ, Fac Chem, Gronostajowa 2, PL-30387 Krakow, Poland

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 35期

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

Multicomponent reactions; Boron; Ugi reaction; C-C coupling; Structure elucidation; BORONIC ACIDS; PYRAZINES; PLATFORM; ANALOGS;

D O I：

10.1002/ejoc.201901187

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.

引用

页码：6132 / 6137

页数：6

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