Protein-protein interaction networks: how can a hub protein bind so many different partners?

被引：105

作者：

Tsai, Chung-Jung ^{[1
]}

Ma, Buyong ^{[1
]}

Nussinov, Ruth ^{[1
,2
]}

机构：

[1] NCI, Ctr Canc Res Nanobiol Program, SAIC Frederick Inc, Frederick, MD 21702 USA

[2] Tel Aviv Univ, Sackler Sch Med, Dept Human Genet & Mol Med, Sackler Inst Mol Med, IL-69978 Tel Aviv, Israel

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 12期

基金：

美国国家卫生研究院;

关键词：

ALTERNATIVE TRANSLATION INITIATION; SYSTEMS BIOLOGY APPROACH; SACCHAROMYCES-CEREVISIAE; FUNCTIONAL DIVERSITY; INTRINSIC DISORDER; HUMAN GENOME; CELL-CYCLE; RECOGNITION; SPECIFICITY; INSIGHTS;

D O I：

10.1016/j.tibs.2009.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

How can a single hub protein bind so many different partners? Numerous studies have sought differences between hubs and non-hubs to explain what makes a protein a hub and how a shared hub-binding site can be promiscuous, yet at the same time be specific. Here, we suggest that the problem is largely non-existent and resides in the popular representation of protein interaction networks: protein products derived from a single gene, even if different, are clustered in maps into a single node. This leads to the impression that a single protein binds to a very large number of partners. In reality, it does not; rather, protein networks reflect the combination of multiple proteins, each with a distinct conformation.

引用

页码：594 / 600

页数：7

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