Magnesium chloride (MgCl2) catalyzed highly regioselective C-3 ring opening of 2,3 epoxy alcohols by N-nucleophile

被引：8

作者：

Kumar, Amit ^{[1
]}

Panda, Gautam ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2021年 / 70卷

关键词：

Magnesium chloride; Regioselective C-3 ring opening; 2,3 Epoxy alcohols; N-Nucleophile; Azides; 2,3-EPOXY ALCOHOLS; METAL; EPOXYALCOHOLS; DERIVATIVES; EPOXIDES; AMINES; SCOPE;

D O I：

10.1016/j.tetlet.2021.153013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report Magnesium chloride (MgCl2) catalyzed first highly C3-selective ring-opening reaction of various 2,3-epoxy alcohols with assorted N-Nucleophiles and sodium azide to furnish 3-amino-1,2 diols and 3-azido-1,2 diols respectively in high yields under mild reaction conditions. This protocol attributes the use of catalytic amount of Magnesium chloride (MgCl2), simple reaction conditions, practical operation and broad functional group tolerance. (C) 2021 Elsevier Ltd. All rights reserved.

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页数：7

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