A mini-review of the diffusion dynamics of DNA-binding proteins: experiments and models

被引：8

作者：

Park, Seongyu ^{[1
]}

Lee, O-chul ^{[1
]}

Durang, Xavier ^{[1
]}

Jeon, Jae-Hyung ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Phys, Pohang 37673, South Korea

来源：

JOURNAL OF THE KOREAN PHYSICAL SOCIETY | 2021年 / 78卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

DNA-binding protein; Anomalous diffusion; Sliding; Hopping; Facilitated diffusion; T7; RNA-POLYMERASE; ONE-DIMENSIONAL DIFFUSION; TUMOR-SUPPRESSOR P53; MOLECULE IMAGING REVEALS; ANOMALOUS DIFFUSION; FACILITATED DIFFUSION; TELOMERIC DNA; 1D DIFFUSION; RANDOM-WALK; SINGLE;

D O I：

10.1007/s40042-021-00060-y

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

In the course of various biological processes, specific DNA-binding proteins must efficiently find a particular target sequence/protein or a damaged site on the DNA. DNA-binding proteins perform this task based on diffusion. Nevertheless, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated and, further, protein specific. In this review, we collect experimental and theoretical studies that quantify the diffusion dynamics of DNA-binding proteins and review them from the viewpoint of diffusion processes.

引用

页码：408 / 426

页数：19

共 130 条

[1] Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA [J].