SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-ARYL-1-(2-BENZOFURYL)-2-PROPEN-1-ONE ANALOGUES

被引：0

作者：

Yadav, D. Bodke ^{[1
]}

Venkatesh, K. B. ^{[1
]}

Sangapure, S. S. ^{[2
]}

机构：

[1] Kuvempu Univ, Dept Studies & Res Ind Chem, Shankaraghatta 577451, India

[2] Gulbarga Univ, Dept Studies & Res Chem, Gulbarga 585106, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 19卷 / 02期

关键词：

3,2-D PYRIMIDINE-DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Claisen-Schmidt condensation of 2-acetyl benzofuran 1 with aromatic aldehydes in presence of strong alkali gave 3-aryl-1-(2-benzofuryl)-2-propen-1-ones 2a-c. Reaction of 2a-c with guanidine nitrate in ethanol in presence of sodium hydroxide yielded 2-amino6-aryl-4-(benzofuran-2-yl) pyrimidines 3a-c. The reactions of 3a-c with different reagents furnished compounds 4,5,6 and 7. Newly synthesized compounds were evaluated for their antimicrobial and antiinflammatory activities.

引用

页码：117 / 120

页数：4