Spatially resolved transcriptomics in neuroscience

被引：56
|
作者：
Close, Jennie L. [1 ]
Long, Brian R. [1 ]
Zeng, Hongkui [1 ]
机构：
[1] Allen Inst Brain Sci, Seattle, WA 98103 USA
来源：
NATURE METHODS | 2021年 / 18卷 / 01期
关键词：
CELL-TYPES; RNA;
D O I：
10.1038/s41592-020-01040-z
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
One major challenge in neuroscience is to gain a systematic understanding of the extraordinary diversity of brain cell types and how they contribute to brain function. Spatially resolved transcriptomics holds unmatched promise in unraveling the organization of brain cell types and their relationship with connectivity, circuit dynamics, behavior and disease. Here we discuss neuroscience applications of various spatially resolved transcriptomics methods, as well as technical challenges that need to be overcome to realize their full potentials.
引用
收藏
页码：23 / 25
页数：3
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