Evaluation of neo-angiogenesis in a case of chordoid meningioma

被引：10

作者：

Barresi, Valeria ^{[1
]}

Tuccari, Giovanni ^{[1
]}

机构：

[1] Univ Messina, Dept Human Pathol, Policlin Univ G Martino, I-98125 Messina, Italy

来源：

JOURNAL OF NEURO-ONCOLOGY | 2009年 / 95卷 / 03期

关键词：

Chordoid meningioma; Neo-angiogenesis; Endoglin; VEGF; Semaphorin3a; Neuropilin-1;

D O I：

10.1007/s11060-009-9942-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and VEGF-R1 expression, was encountered in this tumor. By contrast, the anti-angiogenic factor semaphorin3A, highly expressed in this chordoid meningioma, was ineffective because of the absence of its receptor neuropilin-1. We suggest that VEGF expression and MVD may represent significant prognostic factors in chordoid meningiomas.

引用

页码：445 / 447

页数：3

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