Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

被引：201

作者：

Chen, AS

Metzger, JM

Trumbauer, ME

Guan, XM

Yu, H

Frazier, EG

Marsh, DJ

Forrest, MJ

Gopal-Truter, S

Fisher, J

Camacho, RE

Strack, AM

Mellin, TN

MacIntyre, DE

Chen, HY

Van der Ploeg, LHT ^{[1
]}

机构：

[1] Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Anim Pharmacol, Rahway, NJ 07065 USA

[3] Merck Res Labs, Dept Comparat Med, Rahway, NJ 07065 USA

来源：

TRANSGENIC RESEARCH | 2000年 / 9卷 / 02期

关键词：

food intake; melanocortin-4; receptor; metabolic rate; MT-II;

D O I：

10.1023/A:1008983615045

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.

引用

页码：145 / 154

页数：10

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