Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

被引：201
|
作者：
Chen, AS
Metzger, JM
Trumbauer, ME
Guan, XM
Yu, H
Frazier, EG
Marsh, DJ
Forrest, MJ
Gopal-Truter, S
Fisher, J
Camacho, RE
Strack, AM
Mellin, TN
MacIntyre, DE
Chen, HY
Van der Ploeg, LHT [1 ]
机构：
[1] Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA
[2] Merck Res Labs, Dept Anim Pharmacol, Rahway, NJ 07065 USA
[3] Merck Res Labs, Dept Comparat Med, Rahway, NJ 07065 USA
来源：
TRANSGENIC RESEARCH | 2000年 / 9卷 / 02期
关键词：
food intake; melanocortin-4; receptor; metabolic rate; MT-II;
D O I：
10.1023/A:1008983615045
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.
引用
收藏
页码：145 / 154
页数：10
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