Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

被引：201
|
作者：
Chen, AS
Metzger, JM
Trumbauer, ME
Guan, XM
Yu, H
Frazier, EG
Marsh, DJ
Forrest, MJ
Gopal-Truter, S
Fisher, J
Camacho, RE
Strack, AM
Mellin, TN
MacIntyre, DE
Chen, HY
Van der Ploeg, LHT [1 ]
机构：
[1] Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA
[2] Merck Res Labs, Dept Anim Pharmacol, Rahway, NJ 07065 USA
[3] Merck Res Labs, Dept Comparat Med, Rahway, NJ 07065 USA
来源：
TRANSGENIC RESEARCH | 2000年 / 9卷 / 02期
关键词：
food intake; melanocortin-4; receptor; metabolic rate; MT-II;
D O I：
10.1023/A:1008983615045
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.
引用
收藏
页码：145 / 154
页数：10
相关论文
共 50 条
  • [21] Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice
    Rowland, Neil E.
    Schaub, Jay W.
    Robertson, Kimberly L.
    Andreasen, Amy
    Haskell-Luevano, Carrie
    PEPTIDES, 2010, 31 (12) : 2314 - 2317
  • [22] Identification of melanocortin-4 receptor on osteoclasts
    Evans, JF
    Canas, JA
    Shen, CL
    Aloia, JF
    Yeh, JK
    BONE, 2003, 32 (05) : S150 - S151
  • [23] Point mutations in the melanocortin-4 receptor cause variable obesity in mice
    Thomas P. Meehan
    Koichi Tabeta
    Xin Du
    Lanette S. Woodward
    Karen Firozi
    Bruce Beutler
    Monica J. Justice
    Mammalian Genome, 2006, 17 : 1162 - 1171
  • [24] Point mutations in the melanocortin-4 receptor cause variable obesity in mice
    Meehan, Thomas P.
    Tabeta, Koichi
    Du, Xin
    Woodward, Lanette S.
    Firozi, Karen
    Beutler, Bruce
    Justice, Monica J.
    MAMMALIAN GENOME, 2006, 17 (12) : 1162 - 1171
  • [25] Role of hindbrain melanocortin-4 receptor activity in controlling cardiovascular and metabolic functions in spontaneously hypertensive rats
    do Carmo, Jussara M.
    da Silva, Alexandre A.
    Hall, John E.
    JOURNAL OF HYPERTENSION, 2015, 33 (06) : 1201 - 1206
  • [26] Orally bioavailable melanocortin-4 receptor (MC4R) agonist decreases food intake and body weight in rodents
    Strack, A
    Gorski, J
    Ishihara, A
    Shepherd, C
    Gomori, A
    Palucki, B
    Metzger, J
    Park, M
    Macneil, T
    Weinberg, D
    Wyvratt, M
    Ploeg, LV
    Nargund, R
    MacIntyre, D
    OBESITY RESEARCH, 2004, 12 : A101 - A101
  • [27] The role of the melanocortin system and the melanocortin-4 receptor in ring dove (Streptopelia risoria) feeding behavior
    Strader, AD
    Schiöth, HB
    Buntin, JD
    BRAIN RESEARCH, 2003, 960 (1-2) : 112 - 121
  • [28] Involvement of melanocortin-4 receptor in anxiety and depression
    Chaki, S
    Okuyama, S
    PEPTIDES, 2005, 26 (10) : 1952 - 1964
  • [29] The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
    Tao, Ya-Xiong
    ENDOCRINE REVIEWS, 2010, 31 (04) : 506 - 543
  • [30] THE NATURAL HISTORY OF MELANOCORTIN-4 RECEPTOR DEFICIENCY
    Allen, William
    Roberts, Shearon
    AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2018, 176 (06) : 1485 - 1486
12345